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Effects of Mexiletine, a CYP1A2 Inhibitor, on Tizanidine Pharmacokinetics and Pharmacodynamics
http://hdl.handle.net/2241/108158
http://hdl.handle.net/2241/108158abbabeac-2e5b-41ca-81a3-6593c92e5dde
名前 / ファイル | ライセンス | アクション |
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JCP_50-3.pdf (149.1 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2011-03-10 | |||||
タイトル | ||||||
タイトル | Effects of Mexiletine, a CYP1A2 Inhibitor, on Tizanidine Pharmacokinetics and Pharmacodynamics | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Momo, Kenji
× Momo, Kenji× Homma, Masato× Osaka, Yoshiko× Inomata, Shin-ichi× Tanaka, Makoto× Kohda, Yukinao |
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著者別名 |
本間, 真人
× 本間, 真人× 猪股, 伸一× 田中, 誠× 幸田, 幸直 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The aim of this study was to determine whether mexiletine, a CYP1A2 inhibitor, altered the pharmacokinetics and pharmacodynamics of tizanidine. The pharmacokinetics of tizanidine were examined in an open-label study in 12 healthy participants after a single dose of tizanidine (2 mg) with and without mexiletine coadministration (50 mg, 3 times as a pretreatment for a day and 2 times on the study day). Compared with tizanidine alone, mexiletine coadministration increased the peak plasma concentration (1.8 ± 0.8 vs 5.3 ± 1.8 ng/mL), area under the curve (4.5 ± 2.2 vs 15.4 ± 6.5 ng·h/mL), and the half-life (1.3 ± 0.2 vs 1.8 ± 0.7 h) of tizanidine, respectively (P < .05). Reduction in systolic blood pressure (-10 ± 8 vs -24 ± 7 mm Hg) and diastolic blood pressure (-10 ± 7 vs -18 ± 8 mm Hg) after tizanidine administration was also significantly enhanced by coadministration of mexiletine (P < .01). Of the 15 patients treated with tizanidine and mexiletine, 4 suffered tizanidine-induced adverse effects such as drowsiness and dry mouth in the retrospective survey. Present results suggested that coadministration of mexiletine increased blood tizanidine concentrations and enhanced tizanidine pharmacodynamics in terms of reduction in blood pressure and adverse symptoms. | |||||
書誌情報 |
Journal of clinical pharmacology 巻 50, 号 3, p. 331-337, 発行日 2010-03 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0091-2700 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00695597 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 19789372 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1177/0091270009341961 | |||||
権利 | ||||||
権利情報 | © American College of Clinical Pharmacology, Inc. | |||||
著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | Sage Publications | |||||
URI | ||||||
識別子 | http://hdl.handle.net/2241/108158 | |||||
識別子タイプ | HDL |