{"created":"2021-03-01T06:59:01.464616+00:00","id":21245,"links":{},"metadata":{"_buckets":{"deposit":"4e694eb6-eee3-4676-8b4c-873814299ada"},"_deposit":{"id":"21245","owners":[],"pid":{"revision_id":0,"type":"depid","value":"21245"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00021245","sets":["160:1475","3:62:5591:1340"]},"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-09-21","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"568","bibliographicPageStart":"556","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"International journal of biological sciences"}]}]},"item_5_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"サクハルカル, ミーナ　キショレ"}],"nameIdentifiers":[{}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"In this study the in vitro activities of seven antibiotics (ciprofloxacin, ceftazidime, tetracycline,\ntrimethoprim, sulfamethoxazole, polymyxin B and piperacillin) and six phytochemicals\n(protocatechuic acid, gallic acid, ellagic acid, rutin, berberine and myricetin) against five P.\naeruginosa isolates, alone and in combination are evaluated. All the phytochemicals under\ninvestigation demonstrate potential inhibitory activity against P. aeruginosa. The combinations\nof sulfamethoxazole plus protocatechuic acid, sulfamethoxazole plus ellagic acid, sulfamethoxazole\nplus gallic acid and tetracycline plus gallic acid show synergistic mode of interaction.\nHowever, the combinations of sulfamethoxazole plus myricetin shows synergism for three\nstrains (PA01, DB5218 and DR3062). The synergistic combinations are further evaluated for\ntheir bactericidal activity against P. aeruginosa ATCC strain using time-kill method.\nSub-inhibitory dose responses of antibiotics and phytochemicals individually and in combination\nare presented along with their interaction network to suggest on the mechanism of action\nand potential targets for the phytochemicals under investigation. The identified synergistic\ncombinations can be of potent therapeutic value against P. aeruginosa infections. These\nfindings have potential implications in delaying the development of resistance as the antibacterial\neffect is achieved with lower concentrations of both drugs (antibiotics and phytochemicals).","subitem_description_type":"Abstract"}]},"item_5_identifier_34":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2241/107526"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Ivyspring International Publisher"}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© Ivyspring International Publisher"}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1449-2288","subitem_source_identifier_type":"ISSN"}]},"item_5_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12036598","subitem_source_identifier_type":"NCID"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Jayaraman, Premkumar"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakharkar, Meena K"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Lim, Chu Sing"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tang, Thean Hock"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sakharkar, Kishore R."}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2013-12-25"}],"displaytype":"detail","filename":"IJBS_6-6.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"IJBS_6-6.pdf","url":"https://tsukuba.repo.nii.ac.jp/record/21245/files/IJBS_6-6.pdf"},"version_id":"5c0c69ab-b1d8-4250-8d2e-a24df680e7aa"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Activity and interactions of antibiotic and phytochemical combinations against Pseudomonas aeruginosa in vitro","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Activity and interactions of antibiotic and phytochemical combinations against Pseudomonas aeruginosa in vitro"}]},"item_type_id":"5","owner":"1","path":["1475","1340"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-12-10"},"publish_date":"2010-12-10","publish_status":"0","recid":"21245","relation_version_is_last":true,"title":["Activity and interactions of antibiotic and phytochemical combinations against Pseudomonas aeruginosa in vitro"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2023-07-12T05:31:51.950986+00:00"}