@article{oai:tsukuba.repo.nii.ac.jp:00020680,
 author = {田中, 秀峰 and 田渕, 経司 and 星野, 朝文 and 原, 晃 and Tanaka, Shuho and Tabuchi, Keiji and Hoshino, Tomofumi and Murashita, Hidekazu and Tsuji, Shigeki and Hara, Akira},
 issue = {3},
 journal = {Neuroscience letters},
 month = {Feb},
 note = {GM-1 ganglioside (GM-1), a glycosphingolipid, is embedded in the lipid layer of neuronal membranes and is one of the neuroprotective agents. To the best of our knowledge, the role of GM-1 has never been examined in hair cell injury. The purpose of this study was therefore to evaluate the effects of GM-1 on acoustic injury of the cochlea. Mice were exposed to 4-kHz pure tone of 128 dB SPL (sound pressure level) for 4 h. GM-1 was intraperitoneally administered immediately before the onset of acoustic overexposure. The threshold shift of the auditory brainstem response (ABR) and hair cell loss were then evaluated 2 weeks after acoustic overexposure. Immunostaining for 4-hydroxynonenal (4-HNE), indicative of lipid peroxidation, was also examined in animals subjected to acoustic overexposure. GM-1 treatment significantly decreased the ABR threshold shifts and hair cell loss after acoustic overexposure. And immunostaining for 4-HNE was reduced by GM-1 treatment. These findings suggest that GM-1 is involved in the protection of the cochlea against acoustic injury through inhibiting lipid peroxidation.},
 pages = {237--241},
 title = {Protective effects of exogenous GM-1 ganglioside on acoustic injury of the mouse cochlea},
 volume = {473},
 year = {2010}
}