@article{oai:tsukuba.repo.nii.ac.jp:02002477,
 author = {Shimizu, Shosei and 水本, 斉志 and MIZUMOTO, Masashi and 奥村, 敏之 and OKUMURA, Toshiyuki and Li, Yinuo and Baba, Keiichirou and Murakami, Motohiro and Ishida, Toshiki and Nakamura, Masatoshi and Hiroshima, Yuichi and Iizumi, Takashi and Saito, Takashi and Numajiri, Haruko and 中井, 啓 and NAKAI, Kei and Hata, Masaharu and 櫻井, 英幸 and SAKURAI, Hideyuki},
 journal = {Clinical and Translational Radiation Oncology},
 month = {Mar},
 note = {Background: Hepatic hemangiomas are benign tumors with a favorable prognosis, but giant hepatic
hemangiomas can cause abdominal symptoms and are indicated for treatment. Most cases are treated
with surgery, but radiotherapy has also been used. However, to date, there have been no reports of proton
beam therapy for a hepatic hemangioma.
Case presentation: A 46-year-old woman had a tumor of 80  80 mm in the left medial lobe of the liver,
which was diagnosed as a giant hemangioma based on the contrast pattern. Therapy was required for a
giant hepatic hemangioma with symptoms, but the patient refused blood transfusion due to religious
reasons, which made surgical resection difficult. Therefore, she was referred to our hospital for proton
beam therapy. At her first visit, liver function was Child-Pugh A (5 points) and there was no elevation
of tumor markers. Proton beam therapy of 28.6 Gy (RBE) given in 13 fractions was performed without
interruption. The only observed acute radiation toxicity was Grade 1 dermatitis. One year after proton
beam therapy, the hemangioma had significantly decreased, and a complete response has been maintained
for 15 years based on ultrasound and MRI.
Conclusion: This case is the first reported use of proton beam therapy for a hepatic hemangioma. The outcome
suggests that this treatment may be effective for a giant liver hemangioma.},
 pages = {152--156},
 title = {Proton beam therapy for a giant hepatic hemangioma: A case report and literature review},
 volume = {27},
 year = {2021},
 yomi = {ミズモト, マサシ and オクムラ, トシユキ and ナカイ, ケイ and サクライ, ヒデユキ}
}