{"created":"2021-10-28T03:02:37.950172+00:00","id":2001710,"links":{},"metadata":{"_buckets":{"deposit":"6b98612a-9da1-4321-b97b-338f5c63fb36"},"_deposit":{"created_by":25,"id":"2001710","owner":"25","owners":[25],"owners_ext":{"displayname":"wataka","username":"kuma1008"},"pid":{"revision_id":0,"type":"depid","value":"2001710"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:02001710","sets":["117:7598","3:62:5298:5460"]},"author_link":["205035"],"control_number":"2001710","item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"226","bibliographicPageStart":"220","bibliographicVolumeNumber":"68","bibliographic_titles":[{"bibliographic_title":"Chemical and Pharmaceutical Bulletin","bibliographic_titleLang":"en"}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"This study demonstrates the structure–activity relationship of Col-003, a potent collagen–heat-shock protein 47 (Hsp47) interaction inhibitor. Col-003 analogues were successfully synthesized by Pd(0)-catalyzed cross-coupling reactions of 5-bromosalicylaldehyde derivatives with alkyl–metal species, and the inhibitory activities of the synthetic analogues were evaluated using surface plasmon resonance analysis (BIAcore). We succeeded in discovering two potent inhibitors that showed 85 and 81% inhibition at a concentration of 1.9 µM against the collagen–Hsp47 interaction. This indicates that elongation of an alkyl linker between two aromatic rings could considerably improve inhibitory activity due to the adjustment of a pendant phenyl moiety to an appropriate position, in addition to the hydrophobic interaction with an alkyl linker moiety.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Pharmaceutical Society of Japan","subitem_publisher_language":"en"},{"subitem_publisher":"日本薬学会","subitem_publisher_language":"ja"}]},"item_5_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"31582590","subitem_relation_type_select":"PMID"}}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1248/cpb.c19-00634","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2020 The Pharmaceutical Society of Japan","subitem_rights_language":"en"}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0009-2363","subitem_source_identifier_type":"PISSN"}]},"item_5_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00602100","subitem_source_identifier_type":"NCID"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"吉田, 将人","creatorNameLang":"ja"},{"creatorName":"ヨシダ, マサヒト","creatorNameLang":"ja-Kana"},{"creatorName":"YOSHIDA, Masahito","creatorNameLang":"en"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Saito, Masazumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ito, Shinya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ogawa, Koji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Goshima, Naoki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nagata, Kazuhiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Doi, Takayuki","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-10-28"}],"displaytype":"detail","filename":"CPB_68-3.pdf","filesize":[{"value":"466 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tsukuba.repo.nii.ac.jp/record/2001710/files/CPB_68-3.pdf"},"version_id":"80521201-f2d5-4d49-ace2-a40034510bb3"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Structure–Activity Relationship Study on Col-003, a Protein–Protein Interaction Inhibitor between Collagen and Hsp47","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Structure–Activity Relationship Study on Col-003, a Protein–Protein Interaction Inhibitor between Collagen and Hsp47","subitem_title_language":"en"}]},"item_type_id":"5","owner":"25","path":["7598","5460"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-10-28"},"publish_date":"2021-10-28","publish_status":"0","recid":"2001710","relation_version_is_last":true,"title":["Structure–Activity Relationship Study on Col-003, a Protein–Protein Interaction Inhibitor between Collagen and Hsp47"],"weko_creator_id":"25","weko_shared_id":-1},"updated":"2022-04-27T10:00:49.780012+00:00"}