{"_buckets": {"deposit": "46e44d42-5c33-4e64-ae98-2a25a34b50b1"}, "_deposit": {"created_by": 14, "id": "2001673", "owner": "14", "owners": [14], "owners_ext": {"displayname": "\u5927\u4e45\u4fdd\u5149\u679d", "username": "mokubo"}, "pid": {"revision_id": 0, "type": "depid", "value": "2001673"}, "status": "published"}, "_oai": {"id": "oai:tsukuba.repo.nii.ac.jp:02001673"}, "author_link": ["204589", "204894", "204373", "203871", "204119", "742"], "item_5_biblio_info_6": {"attribute_name": "\u66f8\u8a8c\u60c5\u5831", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020-05", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageStart": "55", "bibliographicVolumeNumber": "13", "bibliographic_titles": [{"bibliographic_title": "Journal of Ovarian Research", "bibliographic_titleLang": "en"}]}]}, "item_5_description_4": {"attribute_name": "\u6284\u9332", "attribute_value_mlt": [{"subitem_description": "Background\nThrombocytosis is related to tumor stage and survival in ovarian cancer in addition to the common complications of malignant diseases, such as anemia and inflammation. The aim of our study was to clarify the precise prognostic impact of pretreatment thrombocytosis in epithelial ovarian cancer.\n\nMethods\nWe retrospectively analyzed 280 consecutive patients who were treated for epithelial ovarian cancer at our institution between 2001 and 2011.\n\nResults\nPretreatment thrombocytosis was observed in 18.9% of all patients and was associated with advanced FIGO stage, primary treatment, operation achievement, histologic subtype, microcytic hypochromic anemia (MHA), and nonmalignant inflammatory condition (P\u2009=\u20090.0018, 0.0028, 0.00050, 0.034, 0.00090 and 0.0022). In the patients who relapsed after primary adjuvant chemotherapy (n\u2009=\u2009126), thrombocytosis was associated with a shorter treatment-free interval (TFI) (P\u2009=\u20090.0091). The univariate and multivariate analyses revealed that thrombocytosis was independently associated with TFI and MHA (P\u2009=\u20090.021 and 0.0091). Patients with thrombocytosis had worse progression-free survival (PFS) and overall survival (OS) than those without thrombocytosis (P\u2009\u003c\u2009 0.0001 and\u2009\u003c\u2009 0.0001). The multivariate analyses for prognostic factors demonstrated that thrombocytosis was significant for poor PFS and OS (P\u2009=\u20090.0050 and 0.022) independent of stage, histology, primary treatment, operation achievement, nonmalignant inflammatory condition and MHA.\n\nConclusions\nThe current findings indicate that the detrimental survival impact of pretreatment thrombocytosis in epithelial ovarian cancer may be independent of tumor extent but rather attributed to chemoresistance, further supporting the therapeutic potential of targeting thrombopoietic cytokines in the disease.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_5_publisher_27": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "BMC", "subitem_publisher_language": "en"}]}, "item_5_relation_10": {"attribute_name": "PubMed\u756a\u53f7", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "32375852", "subitem_relation_type_select": "PMID"}}]}, "item_5_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1186/s13048-020-00651-6", "subitem_relation_type_select": "DOI"}}]}, "item_5_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "\u00a9 The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article\u0027s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article\u0027s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.", "subitem_rights_language": "en"}]}, "item_5_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_5_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1757-2215", "subitem_source_identifier_type": "EISSN"}]}, "item_access_right": {"attribute_name": "\u30a2\u30af\u30bb\u30b9\u6a29", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "\u4e2d\u5c3e, \u7802\u7406", "creatorNameLang": "ja"}, {"creatorName": "\u30ca\u30ab\u30aa, 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[{"subitem_title": "Pretreatment thrombocytosis as an independent predictive factor for chemoresistance and poor survival in epithelial ovarian cancer", "subitem_title_language": "en"}]}, "item_type_id": "5", "owner": "14", "path": ["2780/5696", "2780/5275", "2780/2179", "2780/5695", "2780/5276", "2780/5694", "2780/8116", "3/62/5592/1634626328232"], "permalink_uri": "http://hdl.handle.net/2241/0002001673", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2021-10-25"}, "publish_date": "2021-10-25", "publish_status": "0", "recid": "2001673", "relation": {}, "relation_version_is_last": true, "title": ["Pretreatment thrombocytosis as an independent predictive factor for chemoresistance and poor survival in epithelial ovarian cancer"], "weko_shared_id": -1}