WEKO3
アイテム
{"_buckets": {"deposit": "46e44d42-5c33-4e64-ae98-2a25a34b50b1"}, "_deposit": {"created_by": 14, "id": "2001673", "owner": "14", "owners": [14], "owners_ext": {"displayname": "大久保光枝", "username": "mokubo"}, "pid": {"revision_id": 0, "type": "depid", "value": "2001673"}, "status": "published"}, "_oai": {"id": "oai:tsukuba.repo.nii.ac.jp:02001673", "sets": ["5696", "5275", "2179", "5695", "5276", "5694", "8116", "1634626328232"]}, "author_link": ["204589", "204894", "204373", "203871", "204119", "742"], "item_5_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020-05", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageStart": "55", "bibliographicVolumeNumber": "13", "bibliographic_titles": [{"bibliographic_title": "Journal of Ovarian Research", "bibliographic_titleLang": "en"}]}]}, "item_5_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Background\nThrombocytosis is related to tumor stage and survival in ovarian cancer in addition to the common complications of malignant diseases, such as anemia and inflammation. The aim of our study was to clarify the precise prognostic impact of pretreatment thrombocytosis in epithelial ovarian cancer.\n\nMethods\nWe retrospectively analyzed 280 consecutive patients who were treated for epithelial ovarian cancer at our institution between 2001 and 2011.\n\nResults\nPretreatment thrombocytosis was observed in 18.9% of all patients and was associated with advanced FIGO stage, primary treatment, operation achievement, histologic subtype, microcytic hypochromic anemia (MHA), and nonmalignant inflammatory condition (P = 0.0018, 0.0028, 0.00050, 0.034, 0.00090 and 0.0022). In the patients who relapsed after primary adjuvant chemotherapy (n = 126), thrombocytosis was associated with a shorter treatment-free interval (TFI) (P = 0.0091). The univariate and multivariate analyses revealed that thrombocytosis was independently associated with TFI and MHA (P = 0.021 and 0.0091). Patients with thrombocytosis had worse progression-free survival (PFS) and overall survival (OS) than those without thrombocytosis (P \u003c 0.0001 and \u003c 0.0001). The multivariate analyses for prognostic factors demonstrated that thrombocytosis was significant for poor PFS and OS (P = 0.0050 and 0.022) independent of stage, histology, primary treatment, operation achievement, nonmalignant inflammatory condition and MHA.\n\nConclusions\nThe current findings indicate that the detrimental survival impact of pretreatment thrombocytosis in epithelial ovarian cancer may be independent of tumor extent but rather attributed to chemoresistance, further supporting the therapeutic potential of targeting thrombopoietic cytokines in the disease.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_5_publisher_27": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "BMC", "subitem_publisher_language": "en"}]}, "item_5_relation_10": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "32375852", "subitem_relation_type_select": "PMID"}}]}, "item_5_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1186/s13048-020-00651-6", "subitem_relation_type_select": "DOI"}}]}, "item_5_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article\u0027s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article\u0027s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.", "subitem_rights_language": "en"}]}, "item_5_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_5_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1757-2215", "subitem_source_identifier_type": "EISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "中尾, 砂理", "creatorNameLang": "ja"}, {"creatorName": "ナカオ, サリ", "creatorNameLang": "ja-Kana"}, {"creatorName": "NAKAO, Sari", "creatorNameLang": "en"}], "familyNames": [{"familyName": "中尾", "familyNameLang": "ja"}, {"familyName": "ナカオ", "familyNameLang": "ja-Kana"}, {"familyName": "NAKAO", "familyNameLang": "en"}], "givenNames": [{"givenName": "砂理", "givenNameLang": "ja"}, {"givenName": "サリ", "givenNameLang": "ja-Kana"}, {"givenName": "Sari", "givenNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "204589", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "00647646", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://nrid.nii.ac.jp/ja/nrid/1000000647646"}, {"nameIdentifier": "0000003842", "nameIdentifierScheme": "筑波大学研究者総覧", "nameIdentifierURI": "http://trios.tsukuba.ac.jp/researcher/0000003842"}]}, {"creatorNames": [{"creatorName": "水口, 剛雄", "creatorNameLang": "ja"}, {"creatorName": "ミナグチ, タケオ", "creatorNameLang": "ja-Kana"}, {"creatorName": "MINAGUCHI, Takeo", "creatorNameLang": "en"}], "familyNames": [{"familyName": "水口", "familyNameLang": "ja"}, {"familyName": "ミナグチ", "familyNameLang": "ja-Kana"}, {"familyName": "MINAGUCHI", "familyNameLang": "en"}], "givenNames": [{"givenName": "剛雄", "givenNameLang": "ja"}, {"givenName": "タケオ", "givenNameLang": "ja-Kana"}, {"givenName": "Takeo", "givenNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "204894", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "40372396", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://nrid.nii.ac.jp/ja/nrid/1000040372396"}, {"nameIdentifier": "0000001850", "nameIdentifierScheme": "筑波大学研究者総覧", "nameIdentifierURI": "http://trios.tsukuba.ac.jp/researcher/0000001850"}]}, {"creatorNames": [{"creatorName": "Itagaki, Hiroya", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Hosokawa, Yoshihiko", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "志鎌, あゆみ", "creatorNameLang": "ja"}, {"creatorName": "シカマ, アユミ", "creatorNameLang": "ja-Kana"}, {"creatorName": "SHIKAMA, Ayumi", "creatorNameLang": "en"}], "familyNames": [{"familyName": "志鎌", "familyNameLang": "ja"}, {"familyName": "シカマ", "familyNameLang": "ja-Kana"}, {"familyName": "SHIKAMA", "familyNameLang": "en"}], "givenNames": [{"givenName": "あゆみ", "givenNameLang": "ja"}, {"givenName": "アユミ", "givenNameLang": "ja-Kana"}, {"givenName": "Ayumi", "givenNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "204373", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "40778627", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://nrid.nii.ac.jp/ja/nrid/1000040778627"}, {"nameIdentifier": "0000003944", "nameIdentifierScheme": "筑波大学研究者総覧", "nameIdentifierURI": "http://trios.tsukuba.ac.jp/researcher/0000003944"}]}, {"creatorNames": [{"creatorName": "田坂, 暢崇", "creatorNameLang": "ja"}, {"creatorName": "タサカ, ノブタカ", "creatorNameLang": "ja-Kana"}, {"creatorName": "TASAKA, Nobutaka", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "0000004467", "nameIdentifierScheme": "筑波大学研究者総覧", "nameIdentifierURI": "http://trios.tsukuba.ac.jp/researcher/0000004467"}]}, {"creatorNames": [{"creatorName": "秋山, 梓", "creatorNameLang": "ja"}, {"creatorName": "アキヤマ, アズサ", "creatorNameLang": "ja-Kana"}, {"creatorName": "AKIYAMA, Azusa", "creatorNameLang": "en"}], "familyNames": [{"familyName": "秋山", "familyNameLang": "ja"}, {"familyName": "アキヤマ", "familyNameLang": "ja-Kana"}, {"familyName": "AKIYAMA", "familyNameLang": "en"}], "givenNames": [{"givenName": "梓", "givenNameLang": "ja"}, {"givenName": "アズサ", "givenNameLang": "ja-Kana"}, {"givenName": "Azusa", "givenNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "203871", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "80647272", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://nrid.nii.ac.jp/ja/nrid/1000080647272"}, {"nameIdentifier": "0000003936", "nameIdentifierScheme": "筑波大学研究者総覧", "nameIdentifierURI": "http://trios.tsukuba.ac.jp/researcher/0000003936"}]}, {"creatorNames": [{"creatorName": "越智, 寛幸", "creatorNameLang": "ja"}, {"creatorName": "オチ, ヒロユキ", "creatorNameLang": "ja-Kana"}, {"creatorName": "OCHI, Hiroyuki", "creatorNameLang": "en"}], "familyNames": [{"familyName": "越智", "familyNameLang": "ja"}, {"familyName": "オチ", "familyNameLang": "ja-Kana"}, {"familyName": "OCHI", "familyNameLang": "en"}], "givenNames": [{"givenName": "寛幸", "givenNameLang": "ja"}, {"givenName": "ヒロユキ", "givenNameLang": "ja-Kana"}, {"givenName": "Hiroyuki", "givenNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "204119", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "90574145", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://nrid.nii.ac.jp/ja/nrid/1000090574145"}, {"nameIdentifier": "0000001825", "nameIdentifierScheme": "筑波大学研究者総覧", "nameIdentifierURI": "http://trios.tsukuba.ac.jp/researcher/0000001825"}]}, {"creatorNames": [{"creatorName": "Matsumoto, Koji", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "佐藤, 豊実", "creatorNameLang": "ja"}, {"creatorName": "サトウ, トヨミ", "creatorNameLang": "ja-Kana"}, {"creatorName": "SATOH, Toyomi", "creatorNameLang": "en"}], "familyNames": [{"familyName": "佐藤", "familyNameLang": "ja"}, {"familyName": "サトウ", "familyNameLang": "ja-Kana"}, {"familyName": "SATOH", "familyNameLang": "en"}], "givenNames": [{"givenName": "豊実", "givenNameLang": "ja"}, {"givenName": "トヨミ", "givenNameLang": "ja-Kana"}, {"givenName": "Toyomi", "givenNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "742", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "80344886", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://nrid.nii.ac.jp/ja/nrid/1000080344886"}, {"nameIdentifier": "0000001922", "nameIdentifierScheme": "筑波大学研究者総覧", "nameIdentifierURI": "http://trios.tsukuba.ac.jp/researcher/0000001922"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_access", "date": [{"dateType": "Available", "dateValue": "2021-10-25"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "JOR_13-55.pdf", "filesize": [{"value": "882 KB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_0", "mimetype": "application/pdf", "size": 882000.0, "url": {"objectType": "fulltext", "url": "https://tsukuba.repo.nii.ac.jp/record/2001673/files/JOR_13-55.pdf"}, "version_id": "8e2a6e34-964a-4574-b998-5848770ba6dc"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Pretreatment thrombocytosis as an independent predictive factor for chemoresistance and poor survival in epithelial ovarian cancer", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Pretreatment thrombocytosis as an independent predictive factor for chemoresistance and poor survival in epithelial ovarian cancer", "subitem_title_language": "en"}]}, "item_type_id": "5", "owner": "14", "path": ["5696", "5275", "2179", "5695", "5276", "5694", "8116", "1634626328232"], "permalink_uri": "http://hdl.handle.net/2241/0002001673", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2021-10-25"}, "publish_date": "2021-10-25", "publish_status": "0", "recid": "2001673", "relation": {}, "relation_version_is_last": true, "title": ["Pretreatment thrombocytosis as an independent predictive factor for chemoresistance and poor survival in epithelial ovarian cancer"], "weko_shared_id": -1}
Pretreatment thrombocytosis as an independent predictive factor for chemoresistance and poor survival in epithelial ovarian cancer
http://hdl.handle.net/2241/0002001673
http://hdl.handle.net/2241/000200167378bf63e0-33af-46e7-86fd-31272c7fe4dc
名前 / ファイル | ライセンス | アクション |
---|---|---|
JOR_13-55.pdf (882 KB)
|
Item type | Journal Article(1) | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
公開日 | 2021-10-25 | |||||||||||
タイトル | ||||||||||||
言語 | en | |||||||||||
タイトル | Pretreatment thrombocytosis as an independent predictive factor for chemoresistance and poor survival in epithelial ovarian cancer | |||||||||||
言語 | ||||||||||||
言語 | eng | |||||||||||
資源タイプ | ||||||||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
タイプ | journal article | |||||||||||
アクセス権 | ||||||||||||
アクセス権 | open access | |||||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
著者 |
中尾, 砂理
× 中尾, 砂理× 水口, 剛雄× Itagaki, Hiroya
× Hosokawa, Yoshihiko
× 志鎌, あゆみ× 田坂, 暢崇× 秋山, 梓× 越智, 寛幸× Matsumoto, Koji
× 佐藤, 豊実 |
|||||||||||
抄録 | ||||||||||||
内容記述タイプ | Abstract | |||||||||||
内容記述 | Background Thrombocytosis is related to tumor stage and survival in ovarian cancer in addition to the common complications of malignant diseases, such as anemia and inflammation. The aim of our study was to clarify the precise prognostic impact of pretreatment thrombocytosis in epithelial ovarian cancer. Methods We retrospectively analyzed 280 consecutive patients who were treated for epithelial ovarian cancer at our institution between 2001 and 2011. Results Pretreatment thrombocytosis was observed in 18.9% of all patients and was associated with advanced FIGO stage, primary treatment, operation achievement, histologic subtype, microcytic hypochromic anemia (MHA), and nonmalignant inflammatory condition (P = 0.0018, 0.0028, 0.00050, 0.034, 0.00090 and 0.0022). In the patients who relapsed after primary adjuvant chemotherapy (n = 126), thrombocytosis was associated with a shorter treatment-free interval (TFI) (P = 0.0091). The univariate and multivariate analyses revealed that thrombocytosis was independently associated with TFI and MHA (P = 0.021 and 0.0091). Patients with thrombocytosis had worse progression-free survival (PFS) and overall survival (OS) than those without thrombocytosis (P < 0.0001 and < 0.0001). The multivariate analyses for prognostic factors demonstrated that thrombocytosis was significant for poor PFS and OS (P = 0.0050 and 0.022) independent of stage, histology, primary treatment, operation achievement, nonmalignant inflammatory condition and MHA. Conclusions The current findings indicate that the detrimental survival impact of pretreatment thrombocytosis in epithelial ovarian cancer may be independent of tumor extent but rather attributed to chemoresistance, further supporting the therapeutic potential of targeting thrombopoietic cytokines in the disease. |
|||||||||||
言語 | en | |||||||||||
書誌情報 |
en : Journal of Ovarian Research 巻 13, 号 1, p. 55, 発行日 2020-05 |
|||||||||||
ISSN | ||||||||||||
収録物識別子タイプ | EISSN | |||||||||||
収録物識別子 | 1757-2215 | |||||||||||
PubMed番号 | ||||||||||||
識別子タイプ | PMID | |||||||||||
関連識別子 | 32375852 | |||||||||||
DOI | ||||||||||||
関連タイプ | isIdenticalTo | |||||||||||
識別子タイプ | DOI | |||||||||||
関連識別子 | https://doi.org/10.1186/s13048-020-00651-6 | |||||||||||
権利 | ||||||||||||
言語 | en | |||||||||||
権利情報 | © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. | |||||||||||
著者版フラグ | ||||||||||||
値 | publisher | |||||||||||
出版者 | ||||||||||||
言語 | en | |||||||||||
出版者 | BMC |