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Occupational exposure of platinum-based anti-cancer drugs: five-year monitoring of hair and environmental samples in a single hospital
http://hdl.handle.net/2241/0002001647
http://hdl.handle.net/2241/0002001647b2749c1d-fc8f-4a00-965e-e45e301af9f4
名前 / ファイル | ライセンス | アクション |
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JOMT_15-29.pdf (1.7 MB)
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Item type | Journal Article(1) | |||||||||||||||||||||
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公開日 | 2021-10-19 | |||||||||||||||||||||
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言語 | en | |||||||||||||||||||||
タイトル | Occupational exposure of platinum-based anti-cancer drugs: five-year monitoring of hair and environmental samples in a single hospital | |||||||||||||||||||||
言語 | ||||||||||||||||||||||
言語 | eng | |||||||||||||||||||||
資源タイプ | ||||||||||||||||||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||
タイプ | journal article | |||||||||||||||||||||
アクセス権 | ||||||||||||||||||||||
アクセス権 | open access | |||||||||||||||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||||||
著者 |
堀, 愛
× 堀, 愛× Shimura, Mari
× Iida, Yutaka
× Yamada, Kazuhiko
× Nohara, Kyoko
× Ichinose, Takayuki
× Yamashita, Ai
× Shirataki, Junko
× Hagiwara, Shotaro
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抄録 | ||||||||||||||||||||||
内容記述タイプ | Abstract | |||||||||||||||||||||
内容記述 | Background Occupational exposure to chemotherapeutic agents in hospitals is a critical issue. Here, we focused on occupational exposure to platinum-based anti-cancer drugs (PDs) by evaluating platinum concentrations in hair and environmental workplace samples to monitor the risk among workers. Methods Hospital workers who dealt with or without PDs, patients treated with PDs, and non-medical office workers outside the hospital donated hair samples and completed a questionnaire regarding their history of handling PDs, including any incidents. Hair samples were collected and surface wipe sampling was performed in July 2010 and April 2015, before and after moving to a new building and introducing a revised safety program in August 2010. Samples were analyzed by inductively coupled plasma-mass spectrometry. Results Platinum concentrations in hair from PDs-handling workers was significantly higher than in non-PDs-handling workers (P = 0.045), although 50 times lower than that from PDs-treated patients. Platinum concentrations in the hospital environment had decreased at the second survey 5 years later but had not changed significantly in the hair samples from hospital workers. Conclusion Platinum concentrations in hair are likely dependent on the frequency of handling PDs. Reduced environmental contamination from PDs did not influence platinum levels in hospital workers’ hair. Continuous monitoring by measuring platinum concentrations in the environment and in hair would provide information regarding these issues. |
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言語 | en | |||||||||||||||||||||
書誌情報 |
en : Journal of Occupational Medicine and Toxicology 巻 15, 号 1, p. 29, 発行日 2020-09 |
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収録物識別子タイプ | EISSN | |||||||||||||||||||||
収録物識別子 | 1745-6673 | |||||||||||||||||||||
PubMed番号 | ||||||||||||||||||||||
識別子タイプ | PMID | |||||||||||||||||||||
関連識別子 | 33005211 | |||||||||||||||||||||
DOI | ||||||||||||||||||||||
関連タイプ | isIdenticalTo | |||||||||||||||||||||
識別子タイプ | DOI | |||||||||||||||||||||
関連識別子 | https://doi.org/10.1186/s12995-020-00280-1 | |||||||||||||||||||||
権利 | ||||||||||||||||||||||
言語 | en | |||||||||||||||||||||
権利情報 | © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. | |||||||||||||||||||||
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値 | publisher | |||||||||||||||||||||
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言語 | en | |||||||||||||||||||||
出版者 | BMC |