{"created":"2021-09-28T01:38:53.970072+00:00","id":2001442,"links":{},"metadata":{"_buckets":{"deposit":"3d54d3c2-5bfb-4265-99c4-fc2153991afa"},"_deposit":{"created_by":25,"id":"2001442","owner":"25","owners":[25],"owners_ext":{"displayname":"wataka","username":"kuma1008"},"pid":{"revision_id":0,"type":"depid","value":"2001442"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:02001442","sets":["2780:1283","2780:1781","2780:1975","2780:953","3:62:5298:7829"]},"author_link":["181032","204585","204107","636"],"item_5_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageStart":"1840","bibliographicVolumeNumber":"12","bibliographic_titles":[{"bibliographic_title":"Cancers","bibliographic_titleLang":"en"}]}]},"item_5_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Proton beam therapy (PBT) is a curative treatment for hepatocellular carcinoma (HCC), because it can preserve liver function due to dose targeting via the Bragg peak. However, the degree of direct liver damage by PBT is unclear. In this study, we retrospectively analyzed liver/biliary enzymes and total bilirubin (T-Bil) as markers of direct liver damage during and early after PBT in 300 patients. The levels of these enzymes and bilirubin were almost stable throughout the treatment period. In patients with normal pretreatment levels, aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GGT), and T-Bil were abnormally elevated in only 2 (1.2%), 1 (0.4%), 0, 2 (1.2%), and 8 (3.5%) patients, respectively, and in 8 of these 13 patients (61.5%) the elevations were temporary. In patients with abnormal pretreatment levels, the levels tended to decrease during PBT. GGT and T-Bil were elevated by 1.62 and 1.57 times in patients who received 66 Gy (RBE) in 10 fractions and 74 Gy (RBE) in 37 fractions, respectively, but again these changes were temporary. These results suggest that direct damage to normal liver caused by PBT is minimal, even if a patient has abnormal pretreatment enzyme levels.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_5_publisher_27":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI","subitem_publisher_language":"en"}]},"item_5_relation_10":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"32650519","subitem_relation_type_select":"PMID"}}]},"item_5_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3390/cancers12071840","subitem_relation_type_select":"DOI"}}]},"item_5_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).","subitem_rights_language":"en"}]},"item_5_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"publisher"}]},"item_5_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2072-6694","subitem_source_identifier_type":"EISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sumiya, Taisuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"水本, 斉志","creatorNameLang":"ja"},{"creatorName":"ミズモト, マサシ","creatorNameLang":"ja-Kana"},{"creatorName":"MIZUMOTO, Masashi","creatorNameLang":"en"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Oshiro, Yoshiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Baba, Keiichiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Murakami, Motohiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Shimizu, Shosei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nakamura, Masatoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hiroshima, Yuichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ishida, Toshiki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Iizumi, Takashi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Saito, Takashi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Numajiri, Haruko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"中井, 啓","creatorNameLang":"ja"},{"creatorName":"ナカイ, ケイ","creatorNameLang":"ja-Kana"},{"creatorName":"NAKAI, Kei","creatorNameLang":"en"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"奥村, 敏之","creatorNameLang":"ja"},{"creatorName":"オクムラ, トシユキ","creatorNameLang":"ja-Kana"},{"creatorName":"OKUMURA, Toshiyuki","creatorNameLang":"en"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"櫻井, 英幸","creatorNameLang":"ja"},{"creatorName":"サクライ, ヒデユキ","creatorNameLang":"ja-Kana"},{"creatorName":"SAKURAI, Hideyuki","creatorNameLang":"en"}],"familyNames":[{},{},{}],"givenNames":[{},{},{}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2021-09-28"}],"displaytype":"detail","filename":"Cancers_12-7.pdf","filesize":[{"value":"932 KB"}],"format":"application/pdf","licensetype":"license_0","url":{"objectType":"fulltext","url":"https://tsukuba.repo.nii.ac.jp/record/2001442/files/Cancers_12-7.pdf"},"version_id":"56796852-7bdf-4e65-b9fc-833100117973"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Transitions of Liver and Biliary Enzymes during Proton Beam Therapy for Hepatocellular Carcinoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Transitions of Liver and Biliary Enzymes during Proton Beam Therapy for Hepatocellular Carcinoma","subitem_title_language":"en"}]},"item_type_id":"5","owner":"25","path":["953","1781","1975","1283","7829"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-09-28"},"publish_date":"2021-09-28","publish_status":"0","recid":"2001442","relation_version_is_last":true,"title":["Transitions of Liver and Biliary Enzymes during Proton Beam Therapy for Hepatocellular Carcinoma"],"weko_creator_id":"25","weko_shared_id":-1},"updated":"2022-04-27T10:53:35.129045+00:00"}