{"_buckets": {"deposit": "8477da64-7d72-4237-974e-fc1d6739be56"}, "_deposit": {"created_by": 25, "id": "2001441", "owner": "25", "owners": [25], "owners_ext": {"displayname": "wataka", "username": "kuma1008"}, "pid": {"revision_id": 0, "type": "depid", "value": "2001441"}, "status": "published"}, "_oai": {"id": "oai:tsukuba.repo.nii.ac.jp:02001441", "sets": ["1781", "7829"]}, "author_link": ["204282", "636"], "item_5_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020-06", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "6", "bibliographicPageStart": "1690", "bibliographicVolumeNumber": "12", "bibliographic_titles": [{"bibliographic_title": "Cancers", "bibliographic_titleLang": "en"}]}]}, "item_5_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Background: Androgen deprivation therapy (ADT) combined with radiation therapy benefits intermediate- and high-risk prostate cancer (PC) patients. The optimal ADT duration in combination with high-dose proton beam therapy (PBT) remains unknown. Methods: Intermediate- and high-risk PC patients treated with PBT combined with ADT for various durations were analyzed retrospectively. To assess the relationship between ADT and biochemical relapse-free (bRF) rate, Cox proportional hazards models including T stage, prostate specific antigen (PSA) level, Gleason score (GS), and total radiation dose were used. Results: In the intermediate-risk PC patients (n = 520), ADT use improved bRF (HR 0.49, 95% CI 0.26–0.93; p = 0.029), especially in those with multiple intermediate-risk factors (T2b–2c, PSA 10–20 ng/mL, and GS 7). In the high-risk PC patients (n = 555), a longer ADT duration (\u003e6 months) conferred a benefit for bRF (HR 0.54, 95% CI 0.32–0.90; p = 0.018), which was most apparent in patients with multiple high-risk factors (T3a–4, PSA \u003e 20 ng/mL, and GS ≥ 8) treated with ADT for ≥21 months. Conclusions: Short-term (≤6 months) ADT is beneficial for intermediate-risk PC patients, but likely unnecessary for those with a single risk factor, whereas ADT for \u003e6 months is necessary for high-risk PC patients and ADT for ≥21 months might be optimal for those with multiple risk factors in combination of high-dose PBT.", "subitem_description_language": "en", "subitem_description_type": "Abstract"}]}, "item_5_publisher_27": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "MDPI", "subitem_publisher_language": "en"}]}, "item_5_relation_10": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "32630494", "subitem_relation_type_select": "PMID"}}]}, "item_5_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.3390/cancers12061690", "subitem_relation_type_select": "DOI"}}]}, "item_5_relation_9": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.3390/cancers12061690", "subitem_relation_type_select": "DOI"}}]}, "item_5_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).", "subitem_rights_language": "en"}]}, "item_5_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_5_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "2072-6694", "subitem_source_identifier_type": "EISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "open access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_abf2"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Murakami, Motohiro", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ishikawa, Hitoshi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Shimizu, Shosei", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Iwata, Hiromitsu", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Okimoto, Tomoaki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Takagi, Masaru", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Murayama, Shigeyuki", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Akimoto, Tetsuo", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Wada, Hitoshi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Arimura, Takeshi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Sato, Yoshitaka", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "五所, 正彦", "creatorNameLang": "ja"}, {"creatorName": "ゴショ, マサヒコ", "creatorNameLang": "ja-Kana"}, {"creatorName": "GOSHO, Masahiko", "creatorNameLang": "en"}], "familyNames": [{"familyName": "五所", "familyNameLang": "ja"}, {"familyName": "ゴショ", "familyNameLang": "ja-Kana"}, {"familyName": 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"path": ["3074", "1781", "7829"], "permalink_uri": "http://hdl.handle.net/2241/0002001441", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2021-09-28"}, "publish_date": "2021-09-28", "publish_status": "0", "recid": "2001441", "relation": {}, "relation_version_is_last": true, "title": ["Optimal Androgen Deprivation Therapy Combined with Proton Beam Therapy for Prostate Cancer: Results from a Multi-Institutional Study of the Japanese Radiation Oncology Study Group"], "weko_shared_id": -1}
Optimal Androgen Deprivation Therapy Combined with Proton Beam Therapy for Prostate Cancer: Results from a Multi-Institutional Study of the Japanese Radiation Oncology Study Group
http://hdl.handle.net/2241/0002001441
http://hdl.handle.net/2241/0002001441