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Proteoglycan form of macrophage colony-stimulating factor binds low density lipoprotein
http://hdl.handle.net/2241/102309
http://hdl.handle.net/2241/102309b47ae41b-d0b4-4598-85e7-6f94253a73c3
名前 / ファイル | ライセンス | アクション |
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JCI_94-4.pdf (1.0 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2009-04-27 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Proteoglycan form of macrophage colony-stimulating factor binds low density lipoprotein | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
Suzu, S
× Suzu, S× Inaba, T× Yanai, N× Kawashima, T× 山田, 信博× Oka, T× Machinami, R× Ohtsuki, T× Kimura, F× Kondo, S× Torikata, C× Nagata, N× Motoyoshi, K |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We recently isolated a proteoglycan form of macrophage colony-stimulating factor (PG-M-CSF) that carries a chondroitin sulfate glycosaminoglycan chain. Here, we examined the interaction of PG-M-CSF with low density lipoprotein (LDL). When LDL preincubated with PG-M-CSF was fractionated by molecular size sieving chromatography, it was eluted earlier than untreated LDL. When LDL was preincubated with chondroitin sulfate-free 85-kD M-CSF instead of PG-M-CSF, the elution profile of LDL remained unchanged, indicating specific interaction between PG-M-CSF and LDL. The level of PG-M-CSF binding in the wells of a plastic microtitration plate precoated with LDL was significant, this binding being completely abolished by pretreatment of PG-M-CSF with chondroitinase AC, which degrades chondroitin sulfate. The addition of exogenous chondroitin sulfate or apolipoprotein B inhibited the binding of PG-M-CSF to LDL in a dose-dependent manner, indicating that the interaction between PG-M-CSF and LDL was mediated by the binding of the chondroitin sulfate chain of PG-M-CSF to LDL apolipoprotein B. PG-M-CSF was also demonstrated in the arterial wall, and there were increased amounts of PG-M-CSF in atherosclerotic lesions. The in vitro interaction between PG-M-CSF and LDL thus appears to have physiological significance. | |||||
言語 | en | |||||
書誌情報 |
en : The journal of clinical investigation 巻 94, 号 4, p. 1637-1641, 発行日 1994-10 |
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ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0021-9738 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00695520 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 7929840 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1172/JCI117506 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | © The American Society for Clinical Investigation | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | The American Society for Clinical Investigation |