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Inhibition of diet-induced atheroma formation in transgenic mice expressing apolipoprotein E in the arterial wall
http://hdl.handle.net/2241/102307
http://hdl.handle.net/2241/1023072e191c7a-8936-4c95-a1d3-87e3c426b3eb
名前 / ファイル | ライセンス | アクション |
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JCI_95-2.pdf (2.8 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2009-04-27 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Inhibition of diet-induced atheroma formation in transgenic mice expressing apolipoprotein E in the arterial wall | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
Shimano, H
× Shimano, H× Ohsuga, J× Shimada, M× Namba, Y× Gotoda, T× Harada, K× Katsuki, M× Yazaki, Y× 山田, 信博 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Apolipoprotein E (apoE) plays a crucial role in lipoprotein metabolism both in plasma and in peripheral tissues. To test whether apoE in the vascular wall has a direct and local effect on atherogenesis, we established transgenic mice expressing human apoE under control of H2 Ld promoter. Studies on mRNA levels and immunohistochemistry demonstrated that this line was characterized by high expression of human apoE in the arterial wall while its expression was relatively low in other tissues as compared with the respective endogenous expression of mouse apoE. They showed no difference in plasma cholesterol levels and lipoprotein profile from controls when fed both normal and atherogenic diets. However, after 24 wk of an atherogenic diet, the formation of fatty streak lesions in proximal aorta was markedly inhibited in transgenic mice as compared with controls. Both lesion area and esterified cholesterol content were < 30% of those in controls. In a tissue cholesterol labeling study with 3H-cholesterol, the specific activity of aorta cholesterol was much less in transgenic mice, suggesting that apoE enhances cholesterol efflux from the aortic wall into plasma. Thus, apoE has anti-atherogenic action which is mediated via enhancing reverse cholesterol transport from arterial wall | |||||
言語 | en | |||||
書誌情報 |
en : The journal of clinical investigation 巻 95, 号 2, p. 469-476, 発行日 1995-02 |
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ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 0021-9738 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00695520 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 7860728 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1172/JCI117687 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | © The American Society for Clinical Investigation | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | The American Society for Clinical Investigation |