@article{oai:tsukuba.repo.nii.ac.jp:00017618,
 author = {Inaba, Toshimori and Gotoda, Takanari and Harada, Kenji and Shimada, Masako and Ohsuga, Jun-ichi and Ishibashi, Shun and Yazaki, Yoshio and 山田, 信博 and YAMADA, Nobuhiro},
 issue = {3},
 journal = {The journal of clinical investigation},
 month = {Mar},
 note = {Vascular medial smooth muscle cells migrate, proliferate and transform to foam cells in the process of atherosclerosis. We have reported that the intimal smooth muscle cells express proto-oncogene c-fms, a characteristic gene of monocyte-macrophages, which is not normally expressed in medial smooth muscle cells. In the present study, we demonstrated that combinations of platelet-derived growth factor (PDGF)-BB and either epidermal growth factor (EGF) or fibroblast growth factor (FGF) induced high expression of c-fms in normal human medial smooth muscle cells to the level of intimal smooth muscle cells or monocyte-derived macrophages, whereas c-fms expression by PDGF-BB alone was 1/10 and both EGF and FGF had no independent effect on c-fms expression. By contrast, interferon (IFN)-gamma and macrophage colony-stimulating factor (M-CSF) suppressed the induction of c-fms expression. These results indicate that multiple growth factors and cytokines may play a role in the phenotypic transformation of medial smooth muscle cells to intimal smooth muscle cells in atherosclerotic lesions by altering c-fms expression.},
 pages = {1133--1139},
 title = {Induction of sustained expression of proto-oncogene c-fms by platelet-derived growth factor, epidermal growth factor, and basic fibroblast growth factor, and its suppression by interferon-gamma and macrophage colony-stimulating factor in human aortic medial smooth muscle cells},
 volume = {95},
 year = {1995},
 yomi = {ヤマダ, ノブヒロ}
}