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Although IgA and IgM bind to Fc alpha/mu R, the molecular and structural characteristics of the ligand-receptor interactions have been undetermined. Here, we developed twelve monoclonal antibodies (mAbs) against murine Fc alpha/mu R by. P se blocking immunizing mice deficient in Fc alpha/mu R gene. Eight mAbs totally or partially blocked IgA and IgM bindings to Fc alpha/mu R. The mAbs bound to a peptide derived from the Ig-like domain of murine Fc alpha/mu R, which is conserved not only in human and rat Fc alpha/mu R but also in polymeric Ig receptor (poly-IgR), another Fc receptor for IgA and IgM. These results suggest that IgA and IgM bind to an epitope in the conserved amino acids in the Ig-like domain of Fc alpha/mu R as well as poly-IgR.", "subitem_description_type": "Abstract"}]}, "item_5_identifier_34": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_identifier_type": "HDL", "subitem_identifier_uri": "http://hdl.handle.net/2241/102010"}]}, "item_5_publisher_27": {"attribute_name": "\u51fa\u7248\u8005", "attribute_value_mlt": [{"subitem_publisher": "ACADEMIC PRESS INC ELSEVIER SCIENCE"}]}, "item_5_relation_10": {"attribute_name": "PubMed\u756a\u53f7", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "16681999", "subitem_relation_type_select": "PMID"}}]}, "item_5_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1016/j.bbrc.2006.04.084", "subitem_relation_type_select": "DOI"}}]}, "item_5_rights_12": {"attribute_name": "\u6a29\u5229", "attribute_value_mlt": [{"subitem_rights": "(C)\u3000 2006 Elsevier Inc."}]}, "item_5_select_15": {"attribute_name": "\u8457\u8005\u7248\u30d5\u30e9\u30b0", "attribute_value_mlt": [{"subitem_select_item": "author"}]}, "item_5_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0006-291X", "subitem_source_identifier_type": "ISSN"}]}, "item_5_source_id_9": {"attribute_name": "\u66f8\u8a8c\u30ec\u30b3\u30fc\u30c9ID", "attribute_value_mlt": [{"subitem_source_identifier": "AA00564395", "subitem_source_identifier_type": "NCID"}]}, "item_5_subject_20": {"attribute_name": "NII\u30b5\u30d6\u30b8\u30a7\u30af\u30c8", "attribute_value_mlt": [{"subitem_subject": "\u533b\u5b66", "subitem_subject_scheme": "Other"}]}, "item_creator": {"attribute_name": "\u8457\u8005", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Cho, Yukiko"}], "nameIdentifiers": [{"nameIdentifier": "62291", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Usui, Kenta"}], "nameIdentifiers": [{"nameIdentifier": "62292", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Honda, Shin-ichiro"}], "nameIdentifiers": [{"nameIdentifier": "62293", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tahara-Hanaoka, Satoko"}], "nameIdentifiers": [{"nameIdentifier": "62294", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shibuya, Kazuko"}], "nameIdentifiers": [{"nameIdentifier": "62295", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shibuya, Akira"}], "nameIdentifiers": [{"nameIdentifier": "62296", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "\u30d5\u30a1\u30a4\u30eb\u60c5\u5831", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2013-12-19"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": 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