{"created":"2021-03-01T06:50:07.118984+00:00","id":13682,"links":{},"metadata":{"_buckets":{"deposit":"c0ed0179-902c-4d52-942c-b590564e06a3"},"_deposit":{"id":"13682","owners":[],"pid":{"revision_id":0,"type":"depid","value":"13682"},"status":"published"},"_oai":{"id":"oai:tsukuba.repo.nii.ac.jp:00013682","sets":["3:267:271"]},"item_12_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2000","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_12_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yamanaka, Akihiro"}],"nameIdentifiers":[{"nameIdentifier":"50012","nameIdentifierScheme":"WEKO"}]}]},"item_12_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_12_description_26":{"attribute_name":"目次","attribute_value_mlt":[{"subitem_description":"ラット悩室内へのオレキシン　：　A持続投与は明期の摂取量を増加させたが、体重増加には影響はなかった ~ 山中、章弘","subitem_description_type":"Other"}]},"item_12_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Orexins(orexin-A and -B)are recently identified neuropeptides,which are thought to be implicated in the regulation of feeding behavior. We used a NPY-Y1 receptor specific antagonist,BIBO3304,to examine whether NPY is involved in orexin-induced feeding behavior. Intracerebroventricularadministration of orexin-A(10 nmol)induced food intake in rats(food in take for 3 hr;vehicle 0.3 ± 0.2 g vs,orexin-A 10 nmol, 4.0 ± 0.5 g, n=4).Orexin-induced feeding behavior was partially inhibited by prioradministration of BIBO3304(3 hr food intake:orexin-A 10 nmol,4.0±0.5g vs,BIBO3304(60μg)+orexin-A 10nmol,2.2±0.2g,n=4).A low dose of BIBO3304(30μg）did not show a significant inhibitory effect.BIBO3457,an inactive enantiomer,used as a negative control,did not show any inhibitory effect on orexin-A-induced feeding behavior. c-Fos expression was observed in NPY-containing neurons in the arcuate nucleus 1 hr after orexin-A(10 nmol)was administered intracerebroventricularly control 0.3 ± 0.08%,orexin-A 10.2 ±0.8%,n=5 rats/group).These observations suggest that the NPY pathway is involved in orexin-induced feeding behavior.However,BIBO3304 could not completely abolish the effect of orexin-A.These results suggest that orexin-A elicits feeding behavior partially via the NPY pathway.The NPY system could be the one of downstream pathways by which orexin-A induces feeding behavior. Another pathway may also be involved in orexin-A-induced feeding behavior, because BIBO3304 did not completely abolish orexin-A-induced feeding behavior.","subitem_description_type":"Abstract"}]},"item_12_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Thesis (Ph. D. in Medical Sciences)--University of Tsukuba, (A), no. 2393, 2000.3.24","subitem_description_type":"Other"},{"subitem_description":"Joint authors: Takeshi Sakurai ... [et al.]","subitem_description_type":"Other"},{"subitem_description":"Offprint. Originally published: Brain Research, v. 849, pp. 248-252, 1999","subitem_description_type":"Other"},{"subitem_description":"Includes supplementary treatices","subitem_description_type":"Other"}]},"item_12_identifier_34":{"attribute_name":"URI","attribute_value_mlt":[{"subitem_identifier_type":"HDL","subitem_identifier_uri":"http://hdl.handle.net/2241/1432"}]},"item_12_select_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_select_item":"none"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山中, 章弘"}],"nameIdentifiers":[{"nameIdentifier":"50010","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2013-12-19"}],"displaytype":"detail","filename":"A2393.pdf","filesize":[{"value":"188.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"A2393.pdf","url":"https://tsukuba.repo.nii.ac.jp/record/13682/files/A2393.pdf"},"version_id":"20c68db5-388a-48cd-b040-60ba24f79f6c"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"Chronic intracerebroventricular administration of orexin-A to rats increases food intake in daytime, but has no effect on body weight","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Chronic intracerebroventricular administration of orexin-A to rats increases food intake in daytime, but has no effect on body weight"}]},"item_type_id":"12","owner":"1","path":["271"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-12-03"},"publish_date":"2007-12-03","publish_status":"0","recid":"13682","relation_version_is_last":true,"title":["Chronic intracerebroventricular administration of orexin-A to rats increases food intake in daytime, but has no effect on body weight"],"weko_creator_id":"1","weko_shared_id":null},"updated":"2022-04-27T08:37:54.520331+00:00"}