2024-03-29T09:33:54Z
https://tsukuba.repo.nii.ac.jp/oai
oai:tsukuba.repo.nii.ac.jp:00055897
2022-04-27T09:30:54Z
2780:919
2780:970
3:62:5598:6527
Factors associated with recurrent leptomeningeal metastases in patients with EGFR-mutated non–small-cell lung cancer
佐藤, 浩昭
サトウ, ヒロアキ
SATOH, Hiroaki
檜澤, 伸之
ヒザワ, ノブユキ
HIZAWA, Nobuyuki
Watanabe, Hiroko
Okauchi, Shinichiro
Miyazaki, Kunihiko
An epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) was shown to increase the number of long-term survivors among patients with non–small-cell lung cancer (NSCLC) associated with the mutation of the EGFR gene.1 However, considering the limitations of current medical technology, it is difficult to expect a cure for this disease.2 In most patients, the regrowth of the primary tumor and metastases are observed. Unfortunately, depending on the site of recurrence, treatment of numerous patients with severe metastasis is difficult. Recurrent leptomeningeal metastases are particularly challenging. Meningeal metastasis is defined as a condition in which tumor cells have spread and invaded the surface of the brain and subarachnoid space, and then the ventricles and cisterns via the cerebrospinal fluid.3 The metastasis causes various neurologic symptoms and is often difficult to diagnose.3 As there is no established treatment for cancer recurrence after an effective therapy with an EGFR-TKI, patients may experience a reduced quality of life, become bedridden, and eventually die.3 Therefore, it is important to identify factors that are related to cancer recurrence. In this study, in addition to standard clinicopathological factors, we examined factors related to recurrence in the meninges, which is associated with metastases to other organs.
journal article
Medycyna Praktyczna
2019-11
application/pdf
Polskie archiwum medycyny wewnȩtrznej
11
129
836
838
Polish archives of internal medicine
0032-3772
1897-9483
AA00776928
https://tsukuba.repo.nii.ac.jp/record/55897/files/PAIM_129-11.pdf
eng
31456585
10.20452/pamw.14948
This is an Open Access article distributed under the terms of the Creative Commons Attribution‑NonCommercial‑ShareAlike 4.0 International License (CC BY‑NC‑SA 4.0), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited, distributed under the same license, and used for noncommercial purposes only. For commercial use, please contact the journal office at pamw@mp.pl.