2024-03-28T12:20:58Z
https://tsukuba.repo.nii.ac.jp/oai
oai:tsukuba.repo.nii.ac.jp:00049327
2022-04-27T09:21:52Z
2780:2179
2780:2607
2780:5106
2780:5274
2780:5276
2780:5695
3:62:5598:7294
Human papillomavirus genotype and prognosis of cervical cancer: Favorable survival of patients with HPV16-positive tumors
秋山, 梓
アキヤマ, アズサ
AKIYAMA, Azusa
櫻井, 学
サクライ, マナブ
SAKURAI, Manabu
水口, 剛雄
ミナグチ, タケオ
MINAGUCHI, Takeo
沖, 明典
オキ, アキノリ
OKI, Akinori
佐藤, 豊実
サトウ, トヨミ
SATOH, Toyomi
吉川, 裕之
Onuki, Mamiko
Matsumoto, Koji
Tenjimbayashi, Yuri
Tasaka, Nobutaka
Yoshikawa, Hiroyuki
The prognostic impact of human papillomavirus (HPV) type on invasive cervical cancer (ICC) was analyzed for 137 women treated for ICC at a single institution between 1999 and 2007. The study subjects were divided into three groups according to HPV genotype: HPV16-positive (n = 59), HPV18-positive (n = 33), and HPV16/18-negative ICC (non-HPV16/18, n = 45). The median follow-up time was 102.5 months (range, 5–179). The 10-year overall survival (10y-OS) rates in women with FIGO stage I/II disease were similar among HPV genotypes: 94.7% for HPV16 (n = 39), 95.2% for HPV18 (n = 26), and 96.4% for non-HPV16/18 (n = 29). However, the 10y-OS rates in women with FIGO stage III/IV tumors were 73.7% for HPV16 (n = 20), 45.7% for HPV18 (n = 7), and 35.7% for other types (n = 16), with significantly higher survival in HPV16-positive compared with HPV16-negative ICC (10y-OS; 73.7% vs. 39.5%, P = 0.04). This difference in FIGO stage III/IV tumors remained significant after adjusting for age and histology (hazard ratio 0.30, 95% confidence interval 0.09–0.86, P = 0.02). These results suggest that detection of HPV16 DNA may be associated with a favorable prognosis in patients with FIGO stage III/IV ICC. Given that most women with FIGO stage III/IV tumors received concurrent chemoradiotherapy, this finding may imply that HPV16-positive tumors are more chemoradiosensitive.
journal article
Elsevier
2018-12
application/pdf
Papillomavirus Research
6
41
45
24058521
https://tsukuba.repo.nii.ac.jp/record/49327/files/PR_6-41.pdf
eng
30347290
10.1016/j.pvr.2018.10.005
© 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).