2024-03-28T08:43:22Z
https://tsukuba.repo.nii.ac.jp/oai
oai:tsukuba.repo.nii.ac.jp:00049240
2022-04-27T09:21:46Z
152:2150
3:62:5589:7279
Two novel susceptibility loci for type 2 diabetes mellitus identified by longitudinal exome-wide association studies in a Japanese population
佐久間, 淳
サクマ, ジュン
SAKUMA, Jun
Yasukochi, Yoshiki
Takeuchi, Ichiro
Kato, Kimihiko
Oguri, Mitsutoshi
Fujimaki, Tetsuo
Horibe, Hideki
Yamada, Yoshiji
Recent genome-wide association studies identified genetic variants that confer susceptibility to type 2 diabetes mellitus (T2DM). However, few longitudinal genome-wide association studies of this metabolic disorder have been reported to date. Therefore, we performed a longitudinal exome-wide association study of T2DM, using 24,579 single nucleotide polymorphisms (SNPs) and repeated measurements from 6022 Japanese individuals. The generalized estimating equation model was applied to test relations of SNPs to three T2DM-related parameters: prevalence of T2DM, fasting plasma glucose level, and blood glycosylated hemoglobin content. Three SNPs that passed quality control were significantly (P < 2.26 × 10− 7) associated with two of the three T2DM-related parameters in additive and recessive models. Of the three SNPs, rs6414624 in EVC and rs78338345 in GGA3 were novel susceptibility loci for T2DM. In the present study, the SNP of GGA3 was predicted to be a genetic variant whose minor allele frequency has recently increased in East Asia.
journal article
Elsevier
2019-01
application/pdf
Genomics
1
111
34
42
0888-7543
AA10678346
https://tsukuba.repo.nii.ac.jp/record/49240/files/Genomics_111-1.pdf
eng
29273463
10.1016/j.ygeno.2017.12.010
© 2017 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).