2024-03-28T10:29:29Z
https://tsukuba.repo.nii.ac.jp/oai
oai:tsukuba.repo.nii.ac.jp:00046687
2022-04-27T09:18:42Z
160:1244
160:6763
160:844
3:62:5587:6762
The role of retinoic acid signaling in starfish metamorphosis
守野, 孔明
本多, 正尚
和田, 洋
Yamakawa, Shumpei
Morino, Yoshiaki
Honda, Masanao
Wada, Hiroshi
Background
Although retinoic acid (RA) signaling plays a crucial role in the body patterning of chordates, its function in non-chordate invertebrates, other than its mediation of environmental cues triggering metamorphosis in cnidarians, is largely unknown. We investigated the role of RA signaling in the metamorphosis of starfish (Echinodermata).
Results
We found that exogenous RA treatment induced metamorphosis in starfish larvae. In contrast, inhibitors of RA synthesis and RA receptors suppressed metamorphosis triggered by attachment to a substrate. Gene expressions of the RA signaling component were detected in competent larvae.
Conclusions
This study provides insight into the ancestral function of RA signaling, which is conserved in the metamorphosis of cnidarians and starfish.
journal article
BioMed Central Ltd
2018-04
application/pdf
EvoDevo
1
9
10
2041-9139
https://tsukuba.repo.nii.ac.jp/record/46687/files/ED_9-10.pdf
eng
29721256
10.1186/s13227-018-0098-x
© The Author(s) 2018. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.