2024-03-28T23:04:07Z
https://tsukuba.repo.nii.ac.jp/oai
oai:tsukuba.repo.nii.ac.jp:00036388
2022-04-27T09:05:28Z
2780:922
3:62:5296:4836
Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders
石井, 亜紀子
Yatsuga, Shuichi
Fujita, Yasunori
Ishii, Akiko
Fukumoto, Yoshihiro
Arahata, Hajime
Kakuma, Tatsuyuki
Kojima, Toshio
Ito, Masafumi
Tanaka, Masashi
Saiki, Reo
Koga, Yasutoshi
Objective
The diagnosis of mitochondrial disorders (MDs) is occasionally difficult because patients often present with solitary, or a combination of, symptoms caused by each organ insufficiency, which may be the result of respiratory chain enzyme deficiency. Growth differentiation factor 15 (GDF-15) has been reported to be elevated in serum of patients with MDs. In this study, we investigated whether GDF-15 is a more useful biomarker for MDs than several conventional biomarkers.
Methods
We measured the serum levels of GDF-15 and fibroblast growth factor 21 (FGF-21), as well as other biomarkers, in 48 MD patients and in 146 healthy controls in Japan. GDF-15 and FGF-21 concentrations were measured by enzyme-linked immunosorbant assay and compared with lactate, pyruvate, creatine kinase, and the lactate-to-pyruvate ratio. We calculated sensitivity and specificity and also evaluated the correlation based on two rating scales, including the Newcastle Mitochondrial Disease Rating Scale (NMDAS).
Results
Mean GDF-15 concentration was 6-fold higher in MD patients compared to healthy controls (2,711 ± 2,459 pg/ml vs 462.5 ± 141.0 pg/mL; p < 0.001). Using a receiver operating characteristic curve, the area under the curve was significantly higher for GDF-15 than FGF-21 and other conventional biomarkers. Our date suggest that GDF-15 is the most useful biomarker for MDs of the biomarkers examined, and it is associated with MD severity.
Interpretation
Our results suggest that measurement of GDF-15 is the most useful first-line test to indicate the patients who have the mitochondrial respiratory chain deficiency. Ann Neurol 2015;78:Ann Neurol 2015;78:679–696
journal article
Wiley-Liss
2015-11
application/pdf
Annals of neurology
5
78
814
823
0364-5134
AA00532923
https://tsukuba.repo.nii.ac.jp/record/36388/files/AN_78-5.pdf
eng
26463265
10.1002/ana.24506
© 2015 The Authors Annals of Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.