2024-03-28T11:27:04Z
https://tsukuba.repo.nii.ac.jp/oai
oai:tsukuba.repo.nii.ac.jp:00029331
2022-04-27T08:57:45Z
2780:980
3:62:5594:2057
Association of ADRB2 polymorphism with triglyceride levels in Tongans
大橋, 順
Naka, Izumi
Ohashi, Jun
Kimura, Ryosuke
Inaoka, Tsukasa
Matsumura, Yasuhiro
Background
Our previous study demonstrated that the A-allele of the single nucleotide polymorphism (SNP) rs34623097 located in the upstream region of the β2 adrenergic receptor gene (ADRB2) is significantly associated with risk for obesity in Oceanic populations.
Methods
To investigate whether the ADRB2 polymorphisms explain part of the individual differences in lipid mobilization, energy expenditure and glycogen breakdown, the associations of 10 ADRB2 SNPs with total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglyceride levels were examined in 128 adults in Tonga.
Results
A multiple linear regression analysis adjusted for age, sex, and body mass index revealed that rs34623097 was significantly associated with triglyceride levels (P-value = 0.037). A copy of the rs34623097-A allele increased serum triglyceride levels by 70.1 mg/dL (0.791 mmol/L). None of the ADRB2 SNPs showed a significant association with total-cholesterol, high-density lipoprotein cholesterol, or low-density lipoprotein cholesterol.
Conclusions
In a Tongan population, a SNP located in the upstream region of ADRB2 is associated with triglyceride levels independent of body mass index.
journal article
BioMed Central
2013-07
application/pdf
Lipids in health and disease
12
110
http://hdl.handle.net/2241/119663
1476-511X
https://tsukuba.repo.nii.ac.jp/record/29331/files/LHD_12.pdf
eng
23875540
10.1186/1476-511X-12-110
© 2013 Naka et al.; licensee BioMed Central Ltd.