2024-03-29T05:07:36Z
https://tsukuba.repo.nii.ac.jp/oai
oai:tsukuba.repo.nii.ac.jp:00025199
2022-04-27T08:52:57Z
2778:332
2778:901
3:62:5589:1605
Age Differences in the Relation Between ACTN3 R577X Polymorphism and Thigh-Muscle Cross-Sectional Area in Women
前田, 清司
久野, 譜也
Zempo, Hirofumi
Tanabe, Kai
Murakami, Haruka
Iemitsu, Motoyuki
Maeda, Seiji
Kuno, Shinya
The relation between ACTN3 R577X polymorphism and muscle mass in women has been reported, but its relation to age remains unclear. We investigated the relationship between ACTN3 R577X polymorphism and muscle mass in both middle-aged and elderly women. Two age groups (middle-aged and older) were formed among 162 healthy, nontraining Japanese women (mean±SE, 58.6±0.8 year). Their midthigh-muscle cross-sectional area (CSA) was assessed using magnetic resonance imaging, revealing no difference in thigh-muscle CSA among ACTN3 R577X genotypes in the middle-aged group (XX, 87.3±2.5 cm2; RR&RX, 86.1±1.7 cm2, p=0.7). In contrast, the XX genotype in the older group had a smaller thigh-muscle CSA adjusted to body weight than the RR&RX genotypes (XX, 67.8±2.0 cm2; RR&RX, 72.5±1.2 cm2, p<0.05). The present study showed an association between ACTN3 R577X polymorphism and smaller thigh-muscle CSA in a group of elderly women but not in a group of middle-aged women.
journal article
Mary Ann Liebert
2011-09
application/pdf
Genetic testing and molecular biomarkers
9
15
639
643
http://hdl.handle.net/2241/114062
1945-0265
AA1238373X
https://tsukuba.repo.nii.ac.jp/record/25199/files/GTMB_15-9.pdf
eng
21491997
10.1089/gtmb.2011.0005