2024-03-28T23:42:30Z
https://tsukuba.repo.nii.ac.jp/oai
oai:tsukuba.repo.nii.ac.jp:00020680
2022-04-27T09:45:24Z
2780:1481
3:62:5596:649
Protective effects of exogenous GM-1 ganglioside on acoustic injury of the mouse cochlea
田中, 秀峰
田渕, 経司
星野, 朝文
原, 晃
Tanaka, Shuho
Tabuchi, Keiji
Hoshino, Tomofumi
Murashita, Hidekazu
Tsuji, Shigeki
Hara, Akira
GM-1 ganglioside (GM-1), a glycosphingolipid, is embedded in the lipid layer of neuronal membranes and is one of the neuroprotective agents. To the best of our knowledge, the role of GM-1 has never been examined in hair cell injury. The purpose of this study was therefore to evaluate the effects of GM-1 on acoustic injury of the cochlea. Mice were exposed to 4-kHz pure tone of 128 dB SPL (sound pressure level) for 4 h. GM-1 was intraperitoneally administered immediately before the onset of acoustic overexposure. The threshold shift of the auditory brainstem response (ABR) and hair cell loss were then evaluated 2 weeks after acoustic overexposure. Immunostaining for 4-hydroxynonenal (4-HNE), indicative of lipid peroxidation, was also examined in animals subjected to acoustic overexposure. GM-1 treatment significantly decreased the ABR threshold shifts and hair cell loss after acoustic overexposure. And immunostaining for 4-HNE was reduced by GM-1 treatment. These findings suggest that GM-1 is involved in the protection of the cochlea against acoustic injury through inhibiting lipid peroxidation.
journal article
Elsevier
2010-02
application/pdf
application/pdf
Neuroscience letters
3
473
237
241
http://hdl.handle.net/2241/106955
0304-3940
AA00754925
https://tsukuba.repo.nii.ac.jp/record/20680/files/NSL_473-3.pdf
https://tsukuba.repo.nii.ac.jp/record/20680/files/Fig.pdf
eng
20219629
10.1016/j.neulet.2010.02.057
© 2010 Elsevier Ireland Ltd