2024-03-29T00:49:09Z
https://tsukuba.repo.nii.ac.jp/oai
oai:tsukuba.repo.nii.ac.jp:00017626
2024-01-25T07:45:33Z
2780:761
3:62:5592:675
Apolipoprotein E prevents the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits.
山田, 信博
ヤマダ, ノブヒロ
YAMADA, Nobuhiro
Inoue, Ikuo
Kawamura, Masako
Harada, Kenji
Watanabe, Yoshiro
Shimano, Hitoshi
Gotoda, Takanari
Shimada, Masako
Kohzaki, Kohichi
Tsukada, Toyohiro
Shiomi, Masashi
Watanabe, Yoshio
Yazaki, Yoshio
Apo E plays an important role in plasma lipoprotein metabolism through its high affinity binding to cell surface LDL receptor. In the present study, we studied the effects of apo E on the atherogenic process in Watanabe heritable hyperlipidemic rabbits which are deficient in LDL receptor and an animal model for familial hypercholesterolemia. We isolated apo E from plasma of 1% cholesterol-fed rabbits and administered 10 mg of purified apo E intravenously into five Watanabe heritable hyperlipidemic rabbits three times a week from their age of 2.5 months to 11 months for 8.5 months. After sustained administration to apo E, we found a significant reduction in the accumulation of cholesterol ester in aortae (1.55 +/- 0.07 mg/g tissue) as compared to control rabbits (4.32 +/- 0.61 mg/g tissue). Supporting this, the percentage of the surface area of the aorta with macroscopic plaque was remarkably decreased in apo E-treated animals (18.8 +/- 5.1% vs. 38.8 +/- 8.0% in control). Thus, apo E definitely prevented the progression of atherosclerosis in Watanabe heritable hyperlipidemic rabbits.
journal article
The American Society for Clinical Investigation
1992-02
application/pdf
The journal of clinical investigation
2
89
706
711
0021-9738
AA00695520
https://tsukuba.repo.nii.ac.jp/record/17626/files/JCI_89-2.pdf
eng
1737858
https://doi.org/10.1172/JCI115639
© The American Society for Clinical Investigation
open access