2024-03-28T16:47:58Z
https://tsukuba.repo.nii.ac.jp/oai
oai:tsukuba.repo.nii.ac.jp:00017623
2024-01-25T07:45:27Z
2780:761
3:62:5592:675
Effect of low density lipoprotein receptor deficiency on the metabolism of apolipoprotein B-100 in blood plasma. Kinetic studies in normal and Watanabe heritable hyperlipidemic rabbits
山田, 信博
ヤマダ, ノブヒロ
YAMADA, Nobuhiro
Shames, David M.
Havel, Richard J.
The kinetics of apolipoprotein (apo) B-100 in particles containing apo E (B,E particles) or lacking apo E (B particles) were studied in Watanabe heritable hyperlipidemic (WHHL) rabbits deficient in low density lipoprotein (LDL) receptors, and compared with those of normal rabbits after injection of radioiodinated very low density lipoproteins (VLDL), intermediate density lipoproteins (IDL), and LDL. In both groups results of kinetic modeling were consistent with the hypothesis that all apo B enters the plasma in VLDL, mainly as B,E particles, followed by delipidation and partial conversion to IDL and LDL, with concomitant conversion of some B,E particles to B particles. In WHHL rabbits, production of VLDL apo B was reduced by 40%, but LDL production was increased threefold. Defective removal of B,E and B particles in all three lipoprotein classes, coupled with preserved processes of delipidation, can account for the observed increases in the concentration of apo B (threefold in VLDL, fivefold in IDL, and twenty-twofold in LDL) in WHHL rabbits.
journal article
The American Society for Clinical Investigation
1987-08
application/pdf
The journal of clinical investigation
2
80
507
515
0021-9738
AA00695520
https://tsukuba.repo.nii.ac.jp/record/17623/files/JCI_80-2.pdf
eng
3611356
https://doi.org/10.1172/JCI113099
© The American Society for Clinical Investigation
open access