2024-03-28T21:21:27Z
https://tsukuba.repo.nii.ac.jp/oai
oai:tsukuba.repo.nii.ac.jp:00056210
2022-04-27T09:31:25Z
2780:5360
2780:551
3:62:5600:8166
Redox toxicology of environmental chemicals causing oxidative stress
安孫子, ユミ
アビコ, ユミ
ABIKO, Yumi
熊谷, 嘉人
クマガイ, ヨシト
KUMAGAI, Yoshito
Zheng, Fuli
Gonçalves, Filipe Marques
Li, Huangyuan
Aschner, Michael
© 2020 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Living organisms are surrounded with heavy metals such as methylmercury, manganese, cobalt, cadmium, arsenic, as well as pesticides such as deltamethrin and paraquat, or atmospheric pollutants such as quinone. Extensive studies have demonstrated a strong link between environmental pollutants and human health. Redox toxicity is proposed as one of the main mechanisms of chemical-induced pathology in humans. Acting as both a sensor of oxidative stress and a positive regulator of antioxidants, the nuclear factor erythroid 2-related factor 2 (NRF2) has attracted recent attention. However, the role NRF2 plays in environmental pollutant-induced toxicity has not been systematically addressed. Here, we characterize NRF2 function in response to various pollutants, such as metals, pesticides and atmospheric quinones. NRF2 related signaling pathways and epigenetic regulations are also reviewed.
Elsevier
2020-07
eng
journal article
http://hdl.handle.net/2241/00161612
https://tsukuba.repo.nii.ac.jp/records/56210
32336668
10.1016/j.redox.2020.101475
22132317
Redox Biology
34
101475
https://tsukuba.repo.nii.ac.jp/record/56210/files/RB_34-101475.pdf
application/pdf
1.1 MB
2020-10-19