2024-03-29T11:31:55Z
https://tsukuba.repo.nii.ac.jp/oai
oai:tsukuba.repo.nii.ac.jp:00055260
2022-04-27T09:16:06Z
2780:1272
2780:1982
3:62:5592:8029
Three-dimensional assessment of coronary high-intensity plaques with T1-weighted cardiovascular magnetic resonance imaging to predict periprocedural myocardial injury after elective percutaneous coronary intervention
星, 智也
ホシ, トモヤ
HOSHI, Tomoya
佐藤, 明
サトウ, アキラ
SATO, Akira
Hosoda, Hayato
Asaumi, Yasuhide
Noguchi, Teruo
Morita, Yoshiaki
Kataoka, Yu
Otsuka, Fumiyuki
Nakao, Kazuhiro
Fujino, Masashi
Nagai, Toshiyuki
Nakai, Michikazu
Nishimura, Kunihiro
Kono, Atsushi
Komori, Yoshiaki
Kawasaki, Tomohiro
Izumi, Chisato
Kusano, Kengo
Fukuda, Tetsuya
Yasuda, Satoshi
© The Author(s). 2020 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Background
Periprocedural myocardial injury (pMI) is a common complication of elective percutaneous coronary intervention (PCI) that reduces some of the beneficial effects of coronary revascularization and impacts the risk of cardiovascular events. We developed a 3-dimensional volumetric cardiovascular magnetic resonance (CMR) method to evaluate coronary high intensity plaques and investigated their association with pMI after elective PCI.
Methods
Between October 2012 and October 2016, 141 patients with stable coronary artery disease underwent T1-weighted CMR imaging before PCI. A conventional 2-dimensional CMR plaque-to-myocardial signal intensity ratio (2D-PMR) and the newly developed 3-dimensional integral of PMR (3Di-PMR) were measured. 3Di-PMR was determined as the sum of PMRs above a threshold of > 1.0 for voxels in a target plaque. pMI was defined as high-sensitivity cardiac troponin T > 0.07 ng/mL.
Results
pMI following PCI was observed in 46 patients (33%). 3Di-PMR was significantly higher in patients with pMI than those without pMI. The optimal 3Di-PMR cutoff value for predicting pMI was 51 PMR*mm3 and the area under the receiver operating characteristic curve (0.753) was significantly greater than that for 2D-PMR (0.683, P = 0.015). 3Di-PMR was positively correlated with lipid volume (r = 0.449, P < 0.001) based on intravascular ultrasound.
Stepwise multivariable analysis showed that 3Di-PMR ≥ 51 PMR*mm3 and the presence of a side branch at the PCI target lesion site were significant predictors of pMI (odds ratio [OR], 11.9; 95% confidence interval [CI], 4.6–30.4, P < 0.001; and OR, 4.14; 95% CI, 1.6–11.1, P = 0.005, respectively).
Conclusions
3Di-PMR coronary assessment facilitates risk stratification for pMI after elective PCI.
BioMed Central
2020-01
eng
journal article
http://hdl.handle.net/2241/00160662
https://tsukuba.repo.nii.ac.jp/records/55260
31941517
10.1186/s12968-019-0588-6
10976647
AA11690278
Journal of Cardiovascular Magnetic Resonance
22
1
5
https://tsukuba.repo.nii.ac.jp/record/55260/files/JCMR_22-1.pdf
application/pdf
2.3 MB
2020-08-04