2024-03-29T14:26:41Z
https://tsukuba.repo.nii.ac.jp/oai
oai:tsukuba.repo.nii.ac.jp:00045803
2022-04-27T09:14:25Z
2780:2605
2780:335
2780:4839
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High-sensitivity quantitative analysis reveals the non-linear relationship between the dose and deposition of diphenylarsinic acid in the rat central nervous system following its subchronic exposure
増田, 知之
Masuda, Tomoyuki
Ishii, Kazuhiro
Nakayama, Tomohiro
Iwasaki, Nobuaki
Shibata, Yasuyuki
Tamaoka, Akira
© 2017 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
In the year 2003, the residents of Kamisu, Japan, were exposed to pentavalent organic arsenic diphenylarsinic acid (DPAA[V]) via their normal drinking water. Following the exposure, they developed cerebellar and brainstem symptoms. Although the relatively high dose of DPAA(V) is assumed to have caused their symptoms, the relationship between the exposed dose of DPAA(V) and the level of their deposition in the central nervous system (CNS) remains unclear. Using liquid chromatography–tandem mass spectrometry, we examined the deposition of DPAA(V) and its pentavalent metabolites in the CNS tissues of Crl:CD(SD) rats following the administration of DPAA(V) for 28 days. We found that the concentrations of DPAA(V) in the CNS were very high, given a dose of 5.0 mg/kg/day. However, very low concentrations of DPAA(V) were detected at a dose of 0.3 or 1.2 mg/kg/day, suggesting the absence of a linear dose-response relationship between the dose and deposition of DPAA(V). We also found that this non-linear relationship was commonly observed in various non-CNS tissues, including the excretory system. Our study showed for the first time the exact relationship between the dose and tissue deposition of the organic arsenic following its subchronic administration.
Elsevier
2017-12
eng
journal article
http://hdl.handle.net/2241/00151083
https://tsukuba.repo.nii.ac.jp/records/45803
29225007
10.1016/j.ntt.2017.12.004
08920362
AA1066890X
Neurotoxicology and teratology
65
26
33
https://tsukuba.repo.nii.ac.jp/record/45803/files/NT_65.pdf
application/pdf
479.4 kB
2018-03-29