2024-03-29T14:03:25Z
https://tsukuba.repo.nii.ac.jp/oai
oai:tsukuba.repo.nii.ac.jp:00040800
2022-04-27T09:11:19Z
160:1260
160:523
3:62:5297:5267
Inhibitory Activities of Antioxidant Flavonoids from Tamarix gallica on Amyloid Aggregation Related to Alzheimer's and Type 2 Diabetes Diseases
礒田, 博子
繁森, 英幸
Hmidene, Asma Ben
Hanaki, Mizuho
Murakami, Kazuma
Irie, Kazuhiro
Isoda, Hiroko
Shigemori, Hideyuki
© 2017 The Pharmaceutical Society of Japan
The prevention of amyloid aggregation is promising for the treatment of age-related diseases such as Alzheimer’s (AD) and type 2 diabetes (T2D). Ten antioxidant flavonoids isolated from the medicinal halophyte Tamarix gallica were tested for their amyloid aggregation inhibition potential. Glucuronosylated flavonoids show relatively strong inhibitory activity of Amyloid β (Aβ) and human islet amyloid polypeptide (hIAPP) aggregation compared to their aglycone analogs. Structure–activity relationship of the flavonoids suggests that the catechol moiety is important for amyloid aggregation inhibition, while the methylation of the carboxyl group in the glucuronide moiety and of the hydroxyl group in the aglycone flavonoids decreased it.
Pharmaceutical Society of Japan
2017-02
eng
journal article
http://hdl.handle.net/2241/00145751
https://tsukuba.repo.nii.ac.jp/records/40800
28154265
10.1248/bpb.b16-00801
0918-6158
AA10885497
Biological & pharmaceutical bulletin
40
2
238
241
https://tsukuba.repo.nii.ac.jp/record/40800/files/BRB_40-2.pdf
application/pdf
1.6 MB
2017-04-04