2024-03-29T14:59:04Z
https://tsukuba.repo.nii.ac.jp/oai
oai:tsukuba.repo.nii.ac.jp:00030958
2022-04-27T08:59:36Z
117:148
117:1940
3:62:5592:2048
Glass transition dynamics of anti-inflammatory ketoprofen studied by Raman scattering and terahertz time-domain spectroscopy
柴田, 知彦
森, 龍也
小島, 誠治
Shibata, Tomohiko
Igawa, Hikaru
Kim, Tae Hyun
Mori, Tatsuya
Kojima, Seiji
© 2014 Elsevier B.V. NOTICE: this is the author’s version of a work that was accepted for publication in Journal of molecular structure. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of molecular structure, Volume 1062 (2014) DOI:10.1016/j.molstruc.2014.01.050
A liquid–glass transition and a crystalline state of pharmaceutical racemic ketoprofen were studied by Raman scattering and the broadband terahertz time-domain spectroscopy (THz-TDS) in the frequency range from 9 to 260 cm−1. The low-frequency Raman scattering spectra clearly shows the remarkable change related to a liquid–glass transition at about Tg = 267 K. After melt-quenching at liquid nitrogen temperature, a boson peak appears at about 16.5 cm−1 near and below Tg and the intensity of quasi-elastic scattering related to structural relaxation increases markedly on heating. The crystalline racemic ketoprofen of “conformer A” shows the noncoincidence effect of mode frequencies below 200 cm−1 between Raman scattering spectra and dielectric spectra observed by THz-TDS.
Elsevier
2014
eng
journal article
http://hdl.handle.net/2241/00121474
https://tsukuba.repo.nii.ac.jp/records/30958
10.1016/j.molstruc.2014.01.050
0022-2860
AA00702852
Journal of molecular structure
1062
185
188
https://tsukuba.repo.nii.ac.jp/record/30958/files/JMS_1062.pdf
application/pdf
1.1 MB
2014-06-12