2024-03-28T15:52:21Z
https://tsukuba.repo.nii.ac.jp/oai
oai:tsukuba.repo.nii.ac.jp:00027890
2022-04-27T08:55:51Z
160:1470
2871:2873:296
29:297
3:62:5297:1814
Design, synthesis, and biological evaluation of the analogues of glaziovianin A, a potent antitumor isoflavone
早川, 一郎
臼井, 健郎
木越, 英夫
Hayakawa, Ichiro
Ikedo, Akiyuki
Chinen, Takumi
Usui, Takeo
木越, 英夫
キゴシ, ヒデオ
© 2012 Elsevier Ltd.
NOTICE: this is the author’s version of a work that was accepted for publication in Bioorganic & medicinal chemistry. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in PUBLICATION, 20(19),2012 DOI:10.1016/j.bmc.2012.08.005
Various analogues of glaziovianin A, an antitumor isoflavone, were synthesized, and their biological activities were evaluated. O7-modified glaziovianin A showed strong cytotoxicity against HeLa S3 cells. Compared to glaziovianin A, the O7-benzyl and O7-propargyl analogues were more cytotoxic against HeLa S3 cells and more potent M-phase inhibitors. Furthermore, O7-modified molecular probes of glaziovianin A were synthesized for biological studies.
Elsevier
2012-10
eng
journal article
http://hdl.handle.net/2241/117846
https://tsukuba.repo.nii.ac.jp/records/27890
22921744
10.1016/j.bmc.2012.08.005
0968-0896
AA10938083
Bioorganic & medicinal chemistry
20
19
5745
5756
https://tsukuba.repo.nii.ac.jp/record/27890/files/BMC_20-19.pdf
application/pdf
593.0 kB
2013-12-25