2024-03-29T00:44:54Z
https://tsukuba.repo.nii.ac.jp/oai
oai:tsukuba.repo.nii.ac.jp:00017590
2022-07-14T03:16:03Z
3:62:5591:604
7131:543
DNAM-1, A Novel Adhesion Molecule Involved in the Cytolytic Function of T Lymphocytes
Shibuya, Akira
渋谷, 彰
Campbell, David
Hannum, Charles
Yssel, Hans
Franz-Bacon, Karin
Terrill, McClanahan
Kitamura, Toshio
Nicholl, Jillian
Sutherland, Grant R
Lanie, Lewis L
Phillips, Joseph H
open access
© 1996 Cell Press
Intercellular adhesion molecules play an important role in the generation of T lymphocytemediated immune responses. Here, we describe a novel accessory molecule, DNAX accessory molecule-1 (DNAM-1), that is constitutively expressed on the majority of peripheral blood T lymphocytes. DNAM-1 is a 65 kDa transmembrane glycoprotein consisting of 318 aa includ- ing two immunoglobulin-like domains. Anti-DNAM-1 monoclonal antibody (MAb) inhibits T and NK cellmediated cytotoxicity against a variety of tumor cell targets and blocks cytokine production by alloanti- gen-specific T cells. In addition, DNAM-1 is a tyrosine-phosphorylated signal-transducing molecule that participates in primary adhesion during cytotoxic T lymphocyte (CTL)mediated cytotoxicity.
Elsevier (Cell Press)
1996-06
eng
journal article
AM
http://hdl.handle.net/2241/102273
https://tsukuba.repo.nii.ac.jp/records/17590
8673704
https://doi.org/10.1016/S1074-7613(00)70060-4
1074-7613
AA11006671
Immunity
4
6
573
581
https://tsukuba.repo.nii.ac.jp/record/17590/files/Immunity_4-6.pdf
application/pdf
87.8 kB
2013-12-19