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心不全ラットでの心機能調節における内因性エンドセリン-1の関与 : 不全心筋においてエンドセリン1の産生は著明に増大する
http://hdl.handle.net/2241/6023
http://hdl.handle.net/2241/60238db7a35d-cce9-4fd2-aa2b-705e6abc1415
名前 / ファイル | ライセンス | アクション |
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A1568.pdf (193.4 kB)
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Item type | Thesis or Dissertation(1) | |||||
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公開日 | 2007-07-25 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Endogenous endothelin-1 participates in the maintenance of cardiac function in rats with congestive heart failure : marked increase in endothelin-1 production in the failing heart | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | 心不全ラットでの心機能調節における内因性エンドセリン-1の関与 : 不全心筋においてエンドセリン1の産生は著明に増大する | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_db06 | |||||
タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
酒井, 俊
× 酒井, 俊 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Backgroud Although it was demonstrated that circulaing endothelin (ET)-1 levels are elevated in congestive heart failure(CHF),the producion and roles of ET-1 in the failing heart are not known.We inversigated the producition of ET-1 in the heart and the densilty of myocardial ET reseptors in rats with CHF.We also inverstigated effects of intravenously infused BQ-123,an endothelin-A(ETA) receptor antagonist,on both heart rate and myocardial contractility in rats with CHF.Methods and Results We used the left coronary artery-ligated rat model of CHF(CHF rats.)Three weeks after surgery,the rats developed CHF.Plasma ET-1 concerntration was significantly higher in the CHF rats than in the sham-operated rats(P<.01).In the left ventricle,the expression of prepro ET-1 mRNA was markedly higher in the CHF rats than in the sham-operated rats.The peptide level of ET-1 in the ventricle was also signigicantly higher in the CHF rats than in the sham-operatede rats(500A±41vs 102A±10 Pg/g tissue,p<.01).Myocardial ET receptors were signigicantly higher in the CHF rats than in the sham-operated rats(243A±20vs 155A±17 fmolmg protein,p<05). In the CHF rats,intravenous BQ-123 infusion(0.1 mg/kg/min for120 min)significantly decreased both heart rate (p<.01)and LV+dp/dt max(p<.05),but not mean blood pressure.BQ-123 infusion did not affect these hemodynamic parameters in the sham-operated rats.Conclusions The present study demonstrated that the production of ET-1 in the heart is markedly increased,and the density of myocardial ET receptors is signigicantly elevated in the CHF rats.Intravenous BQ-123 infusion significantly reduced both heart rate and LV+dp/dt max in the CHF rats but not in the sham-operated rats.Therefore,the ET receptormediatde signal transducion system in the heart appers to be markedly stimulated in the CHF rats,and endogenous ET-1 may be involved in the mainterance of the caradiac function in these rats. | |||||
言語 | en | |||||
書誌情報 |
発行日 1996 |
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関係URI | ||||||
関連タイプ | hasFormat | |||||
識別子タイプ | URI | |||||
関連識別子 | https://www.tulips.tsukuba.ac.jp/opac/volume/732843 | |||||
言語 | ja | |||||
関連名称 | 全文はOPACにあり | |||||
取得学位 | ||||||
学位名 | 博士(医学) | |||||
取得学位 | ||||||
学位名 | Doctor of Philosophy in Medical Sciences | |||||
学位授与大学 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 12102 | |||||
言語 | ja | |||||
学位授与機関名 | 筑波大学 | |||||
言語 | en | |||||
学位授与機関名 | University of Tsukuba | |||||
学位授与年度 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 1995 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 1996-03-25 | |||||
報告番号 | ||||||
学位授与番号 | 甲第1568号 |