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Otx gene plays important roles in animal brain and head development and Otx genes are found in all major animal groups: cnidarians, lophotrochozoans, ecdysozoans, and\ndeuterostomes. Ascidians, positioned near the origin of the phylum Chordata, share a conserved set of anteroposterior patterning genes with\nthat of vertebrates. Here I report the cross-phylum regulatory potential of the ascidian Otx gene in the development of the Drosophila brain and the head vertex structures. The ascidian Otx gene rescued the embryonic brain defect of Drosophila caused by null mutation of the orthodenticle (otd) gene and enhanced rostral brain development while it suppressed trunk\nnerve cord formation. Furthermore, the ascidian Otx gene restored the head vertex defects caused by a viable otd mutation, ocelliless, via specific\nactivation and repression of downstream regulatory genes. The crossphylum regulatory potentials of the ascidian Otx gene are equivalent to the activities of the Drosophila and human otd/Otx genes in these developmental processes. In contrast to these results, cnidarian Otx gene showed little functional equivalence in Drosophila. In addition, planarian\nOtx gene had failed to rescue Drosophila embryonic brain development. 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Cross-phylum functional equivalence of Otx genes and the origin of brain patterning
http://hdl.handle.net/2241/6828
http://hdl.handle.net/2241/6828aba3a2d2-b4e8-4495-a374-4446c877152a
名前 / ファイル | ライセンス | アクション |
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A3328.pdf (161.4 kB)
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1.pdf (786.3 kB)
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Item type | Thesis or Dissertation(1) | |||||
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公開日 | 2007-07-25 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Cross-phylum functional equivalence of Otx genes and the origin of brain patterning | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_db06 | |||||
タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
安達, 在嗣
× 安達, 在嗣 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Molecular mechanisms of cephalic development is an intriguing question in evolutionary and developmental biology. Otx gene plays important roles in animal brain and head development and Otx genes are found in all major animal groups: cnidarians, lophotrochozoans, ecdysozoans, and deuterostomes. Ascidians, positioned near the origin of the phylum Chordata, share a conserved set of anteroposterior patterning genes with that of vertebrates. Here I report the cross-phylum regulatory potential of the ascidian Otx gene in the development of the Drosophila brain and the head vertex structures. The ascidian Otx gene rescued the embryonic brain defect of Drosophila caused by null mutation of the orthodenticle (otd) gene and enhanced rostral brain development while it suppressed trunk nerve cord formation. Furthermore, the ascidian Otx gene restored the head vertex defects caused by a viable otd mutation, ocelliless, via specific activation and repression of downstream regulatory genes. The crossphylum regulatory potentials of the ascidian Otx gene are equivalent to the activities of the Drosophila and human otd/Otx genes in these developmental processes. In contrast to these results, cnidarian Otx gene showed little functional equivalence in Drosophila. In addition, planarian Otx gene had failed to rescue Drosophila embryonic brain development. The results with ascidian Otx gene function support the notion that basal chordates such as ascidians have the similar molecular patterningmechanism for the anterior structures found in higher chordates, and suggest a common genetic program of cephalic development among invertebrate, protochordate and vertebrate. ・・・ |
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言語 | en | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Includes bibliographical references | |||||
言語 | en | |||||
書誌情報 |
発行日 2004 |
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取得学位 | ||||||
学位名 | 博士(理学) | |||||
取得学位 | ||||||
学位名 | Doctor of Philosophy in Science | |||||
学位授与大学 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 12102 | |||||
言語 | ja | |||||
学位授与機関名 | 筑波大学 | |||||
言語 | en | |||||
学位授与機関名 | University of Tsukuba | |||||
学位授与年度 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 2003 | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2004-03-25 | |||||
報告番号 | ||||||
学位授与番号 | 甲第3328号 |