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A note on the bias of standard errors when orthogonality of mean and variance parameters is not satisfied in the mixed model for repeated measures analysis
http://hdl.handle.net/2241/00161521
http://hdl.handle.net/2241/00161521f9b9e6c3-3c6b-47bd-9c78-dfc5f68d0a34
名前 / ファイル | ライセンス | アクション |
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SM_39-9 (264.7 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2020-10-01 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | A note on the bias of standard errors when orthogonality of mean and variance parameters is not satisfied in the mixed model for repeated measures analysis | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
丸尾, 和司
× 丸尾, 和司× 五所, 正彦× Ishii, Ryota× Yamaguchi, Yusuke× Doi, Masaaki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The mixed effect models for repeated measures (MMRM) analysis is sometimes used as a primary analysis in longitudinal randomized clinical trials. The SE for the treatment effect in the MMRM analysis is usually estimated by assuming the orthogonality of the fixed effect and variance‐covariance parameters, which is the orthogonality property of a multivariate normal distribution, because of default settings of most standard statistical software. However, this property might be lost when analysis models are misspecified and/or data include missing values with the mechanism of being missing at random. In this study, we investigated the effect of the assumption of the orthogonality property on the estimation of the SE for the MMRM analysis. From simulation and case studies, it was shown that the SE with the assumption of orthogonality property had nonnegligible bias, especially when the analysis models assuming heteroscedasticity between treatment groups were applied. We also introduce the SAS code for the MMRM analysis without assuming the orthogonality property. Assuming the orthogonality property in the MMRM analysis would lead to invalid statistical inference, and it is necessary to be careful when applying the MMRM analysis with most standard software. | |||||
書誌情報 |
en : Statistics in medicine 巻 39, 号 9, p. 1264-1274, 発行日 2020-04 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0277-6715 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10634679 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 31916260 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1002/sim.8474 | |||||
権利 | ||||||
権利情報 | © 2020 John Wiley & Sons, Ltd. | |||||
権利 | ||||||
権利情報 | This is the peer reviewed version of the following article: A note on the bias of standard errors when orthogonality of mean and variance parameters is not satisfied in the mixed model for repeated measures analysis. Statistics in Medicine. 2020;39:1264–1274, which has been published in final form at https://doi.org/10.1002/sim.8474. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | |||||
著者版フラグ | ||||||
値 | author | |||||
出版者 | ||||||
出版者 | Wiley |