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RNA-Sequencing Analysis of Paternal Low-Protein Diet-Induced Gene Expression Change in Mouse Offspring Adipocytes
http://hdl.handle.net/2241/00161365
http://hdl.handle.net/2241/00161365615d29e3-15c5-4430-b2dd-6b42f878ff57
名前 / ファイル | ライセンス | アクション |
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G3_9-7-2161.full (1.6 MB)
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Item type | Journal Article(1) | |||||||||||
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公開日 | 2020-09-16 | |||||||||||
タイトル | ||||||||||||
言語 | en | |||||||||||
タイトル | RNA-Sequencing Analysis of Paternal Low-Protein Diet-Induced Gene Expression Change in Mouse Offspring Adipocytes | |||||||||||
言語 | ||||||||||||
言語 | eng | |||||||||||
資源タイプ | ||||||||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
タイプ | journal article | |||||||||||
著者 |
村谷, 匡史
× 村谷, 匡史
WEKO
204931
× Ly, Nhung Hong× Maekawa, Toshio× Yoshida, Keisuke× Liu, Yang× Ishii, Shunsuke |
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抄録 | ||||||||||||
内容記述タイプ | Abstract | |||||||||||
内容記述 | Increasing evidence indicates that parental diet affects the metabolism and health of offspring. It is reported that paternal low-protein diet (pLPD) induces glucose intolerance and the expression of genes involved in cholesterol biosynthesis in mouse offspring liver. The aim of the present study was to determine the effect of a pLPD on gene expression in offspring white adipose tissue (WAT), another important tissue for the regulation of metabolism. RNA-seq analysis indicated that pLPD up- and down-regulated 54 and 274 genes, respectively, in offspring WAT. The mRNA expression of many genes involved in lipogenesis was down-regulated by pLPD feeding, which may contribute to metabolic disorder. The expression of carbohydrate response element-binding protein β (ChREBP-β), an important lipogenic transcription factor, was also significantly lower in the WAT of pLPD offspring, which may have mediated the down-regulation of the lipogenic genes. By contrast, the LPD did not affect the expression of lipogenic genes in the WAT of the male progenitor, but increased the expression of lipid oxidation genes, suggesting that a LPD may reduce lipogenesis using different mechanisms in parents and offspring. These findings add to our understanding of how paternal diet can regulate metabolism in their offspring. | |||||||||||
書誌情報 |
en : G3: Genes|Genomes|Genetics 巻 9, 号 7, p. 2161-2170, 発行日 2019-07 |
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ISSN | ||||||||||||
収録物識別子タイプ | ISSN | |||||||||||
収録物識別子 | 2160-1836 | |||||||||||
PubMed番号 | ||||||||||||
識別子タイプ | PMID | |||||||||||
関連識別子 | 31289120 | |||||||||||
DOI | ||||||||||||
識別子タイプ | DOI | |||||||||||
関連識別子 | 10.1534/g3.119.400181 | |||||||||||
権利 | ||||||||||||
権利情報 | © 2019 Hong Ly et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/ licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||||||||
著者版フラグ | ||||||||||||
値 | publisher | |||||||||||
出版者 | ||||||||||||
出版者 | Genetics Society of America |