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We sought to characterize the TU wave complex of Andersen–Tawil syndrome type 1 (ATS1) using high frequency electrocardiogram (ECG) data.\nMethods\nElectrocardiograms were recorded as time series data with a 2 kHz frequency ECG amplifier in 13 patients with ATS1 (positive for KCNJ2 mutation, ATS1 group) and age‐matched healthy individuals (control group). Conventional ECG parameters were measured, and principal component analysis (PCA) and independent component analysis (ICA) were applied to the TU wave complex.\nResults\nTime from T peak (Tp) to U peak (Up), time from bottom (B) to Up, and time from B to U end (BUe, U duration) (0.232 ± 0.018 vs. 0.165 ± 0.017, p \u003c .0001), where B is the lowest point between T and U waves, were all longer in the ATS1 group than the control group. Multivariate logistic regression analysis revealed that BUe could completely differentiate the two groups. 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Multivariate analysis of TU wave complex on electrocardiogram in Andersen–Tawil syndrome with KCNJ2 mutations
http://hdl.handle.net/2241/00160227
http://hdl.handle.net/2241/00160227d458c5d0-3392-4cc8-9bd7-beed7eb5a65e
名前 / ファイル | ライセンス | アクション |
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ANE_25-3 (1.2 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2020-06-26 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Multivariate analysis of TU wave complex on electrocardiogram in Andersen–Tawil syndrome with KCNJ2 mutations | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
堀米, 仁志
× 堀米, 仁志× Ishikawa, Yasuhiro× Kokubun, Norito× Yoshinaga, Masao× Sumitomo, Naokata× Lin, Lisheng× Kato, Yoshiaki× Tanabe‐Kameda, Yuri× Ohno, Seiko× Nagashima, Masami× Horie, Minoru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background The exact differences between the TU wave complex of ATS1 and that of healthy individuals remain to be investigated. We sought to characterize the TU wave complex of Andersen–Tawil syndrome type 1 (ATS1) using high frequency electrocardiogram (ECG) data. Methods Electrocardiograms were recorded as time series data with a 2 kHz frequency ECG amplifier in 13 patients with ATS1 (positive for KCNJ2 mutation, ATS1 group) and age‐matched healthy individuals (control group). Conventional ECG parameters were measured, and principal component analysis (PCA) and independent component analysis (ICA) were applied to the TU wave complex. Results Time from T peak (Tp) to U peak (Up), time from bottom (B) to Up, and time from B to U end (BUe, U duration) (0.232 ± 0.018 vs. 0.165 ± 0.017, p < .0001), where B is the lowest point between T and U waves, were all longer in the ATS1 group than the control group. Multivariate logistic regression analysis revealed that BUe could completely differentiate the two groups. PCA ratios in the ATS1 group were significantly larger than the control group (26.5 ± 12.3 vs. 10.4 ± 6.2, p = .0005). ICA revealed 1 or 2 U‐wave‐specific independent components (ICs) that exclusively comprise the U wave in ATS1, whereas U waves in the control group were composed of some ICs that also comprised T waves. Conclusions U‐wave‐related temporal parameters, particularly BUe, and the existence of U‐wave‐specific ICs, extracted in the ICA, are useful for differentiation of U waves in ATS1 from those in healthy individuals. |
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書誌情報 |
en : Annals of Noninvasive Electrocardiology 巻 25, 号 3, 発行日 2020-05 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1082-720X | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11123325 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 31724784 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1111/anec.12721 | |||||
権利 | ||||||
権利情報 | © 2019 The Authors. Annals of Noninvasive Electrocardiology published by Wiley Periodicals, LLC | |||||
権利 | ||||||
権利情報 | This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Wiley |