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In the present study, the antidepressant-like effects of FA in male ICR mice using tail suspension test (TST) are investigated and its molecular mechanisms are explored. Methods and Results Oral administration of FA at a dose of 5 mg kg(-1) for 7 days significantly reduces immobility of mice compared to vehicle-administered control group. Microarray and real-time PCR analyses reveal that FA upregulates the expression of several genes associated with cell survival and proliferation, energy metabolism, and dopamine synthesis in mice limbic system of brain. Interestingly, it is found that FA, unlike antidepressant drug bupropion, strongly promotes energy metabolism. Additionally, FA increases catecholamine (dopamine and noradrenaline), brain-derived neurotrophic factor, and ATP levels, and decreases glycogen levels in the limbic system of the mice brain. 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Antidepressant‐Like Effect of Ferulic Acid via Promotion of Energy Metabolism Activity
http://hdl.handle.net/2241/00159157
http://hdl.handle.net/2241/00159157c95a3f84-06c8-4c67-94ba-6c37391581f7
名前 / ファイル | ライセンス | アクション |
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MNFR_63-19 (755.6 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2019-12-13 | |||||
タイトル | ||||||
タイトル | Antidepressant‐Like Effect of Ferulic Acid via Promotion of Energy Metabolism Activity | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
佐々木, 一憲
× 佐々木, 一憲× 礒田, 博子× Iwata, Nozomu× Ferdousi, Farhana |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Scope Ferulic acid (FA), a natural phenolic phytochemical abundantly present in whole grains, herbs, and dried fruits, exhibits anti-inflammatory, antioxidant, and neuroprotective effects. In the present study, the antidepressant-like effects of FA in male ICR mice using tail suspension test (TST) are investigated and its molecular mechanisms are explored. Methods and Results Oral administration of FA at a dose of 5 mg kg(-1) for 7 days significantly reduces immobility of mice compared to vehicle-administered control group. Microarray and real-time PCR analyses reveal that FA upregulates the expression of several genes associated with cell survival and proliferation, energy metabolism, and dopamine synthesis in mice limbic system of brain. Interestingly, it is found that FA, unlike antidepressant drug bupropion, strongly promotes energy metabolism. Additionally, FA increases catecholamine (dopamine and noradrenaline), brain-derived neurotrophic factor, and ATP levels, and decreases glycogen levels in the limbic system of the mice brain. Conclusion The research provides the first evidence that FA enhances energy production, which can be the underlying mechanism of the antidepressant-like effects of FA observed in this study. | |||||
書誌情報 |
Molecular nutrition & food research 巻 63, 号 19, p. 1900327, 発行日 2019-10 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1613-4125 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 31394019 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1002/mnfr.201900327 | |||||
権利 | ||||||
権利情報 | ©2019 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Wiley |