WEKO3
アイテム
{"_buckets": {"deposit": "42e96833-b0fd-4d7a-b82f-e4aabdf8b7e0"}, "_deposit": {"id": "51878", "owners": [], "pid": {"revision_id": 0, "type": "depid", "value": "51878"}, "status": "published"}, "_oai": {"id": "oai:tsukuba.repo.nii.ac.jp:00051878", "sets": ["1260", "2901"]}, "item_5_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2019-05", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageStart": "1934578X1984303", "bibliographicVolumeNumber": "14", "bibliographic_titles": [{"bibliographic_title": "Natural product communications"}]}]}, "item_5_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Nowadays, the incidence of Alzheimer’s disease (AD) and type 2 diabetes (T2D) is increasing at an alarming rate. More and more studies have been investigating the relationship between these two diseases and are trying to find an effective treatment. According to amyloid hypothesis, it is very necessary to find phenolic compounds with catechol moieties, which would inhibit the aggregation of amyloid β (Aβ) and human islet amyloid polypeptide (hIAPP), while also exhibiting antioxidant activity and protective effect. We isolated rosmarinic acid (RA) from the plant Isodon japonicus (Burm.f.) H. Hara. Thioflavin T assay and transmission electron microscopy observation were carried out to evaluate the inhibitory effect of RA, caffeic acid, and 3,4-dihydroxyphenyllactic acid, which are the substructures of RA, on both Aβ and hIAPP fibrillization. 2,2-Diphenyl-1-picrylhydrazyl assay was applied to test the antioxidant activity. RA showed inhibitory effect on both peptides and strong antioxidant activity. These results suggest that the existence of catechol units plays an important role on the inhibitory activity. Therefore, RA will be a promising strategy to prevent AD and T2D.", "subitem_description_type": "Abstract"}]}, "item_5_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1177/1934578X19843039", "subitem_relation_type_select": "DOI"}}]}, "item_5_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "©The Author(s) 2019"}, {"subitem_rights": "Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www. creativecommons. org/ licenses/ by- nc/ 4. 0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https:// us. sagepub. com/ en- us/ nam/ openaccess- at- sage)."}]}, "item_5_select_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_select_item": "publisher"}]}, "item_5_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1934-578X", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "繁森, 英幸"}, {"creatorName": "シゲモリ, ヒデユキ", "creatorNameLang": "ja-Kana"}, {"creatorName": "SHIGEMORI, Hideyuki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "106733", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "70202108", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://nrid.nii.ac.jp/ja/nrid/1000070202108"}, {"nameIdentifier": "0000001378", "nameIdentifierScheme": "筑波大学研究者総覧", "nameIdentifierURI": "http://trios.tsukuba.ac.jp/researcher/0000001378"}]}, {"creatorNames": [{"creatorName": "Sun, Jiayi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "213693", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Jiang, Gandan", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "213694", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-08-09"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "NPC_14-5.pdf", "filesize": [{"value": "1.7 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_9", "mimetype": "application/pdf", "size": 1700000.0, "url": {"label": "NPC_14-5", "url": "https://tsukuba.repo.nii.ac.jp/record/51878/files/NPC_14-5.pdf"}, "version_id": "ce1388ce-fc5d-47ed-acf0-324cd0badc1b"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Inhibitory Activity on Amyloid Aggregation of Rosmarinic Acid and Its Substructures From Isodon japonicus", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Inhibitory Activity on Amyloid Aggregation of Rosmarinic Acid and Its Substructures From Isodon japonicus"}]}, "item_type_id": "5", "owner": "1", "path": ["1260", "2901"], "permalink_uri": "http://hdl.handle.net/2241/00157307", "pubdate": {"attribute_name": "公開日", "attribute_value": "2019-08-09"}, "publish_date": "2019-08-09", "publish_status": "0", "recid": "51878", "relation": {}, "relation_version_is_last": true, "title": ["Inhibitory Activity on Amyloid Aggregation of Rosmarinic Acid and Its Substructures From Isodon japonicus"], "weko_shared_id": 5}
Inhibitory Activity on Amyloid Aggregation of Rosmarinic Acid and Its Substructures From Isodon japonicus
http://hdl.handle.net/2241/00157307
http://hdl.handle.net/2241/00157307b61a8aa6-3002-49fd-b423-1e365ba132ed
名前 / ファイル | ライセンス | アクション |
---|---|---|
NPC_14-5 (1.7 MB)
|
Item type | Journal Article(1) | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
公開日 | 2019-08-09 | |||||||||||
タイトル | ||||||||||||
タイトル | Inhibitory Activity on Amyloid Aggregation of Rosmarinic Acid and Its Substructures From Isodon japonicus | |||||||||||
言語 | ||||||||||||
言語 | eng | |||||||||||
資源タイプ | ||||||||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
タイプ | journal article | |||||||||||
著者 |
繁森, 英幸
× 繁森, 英幸
WEKO
106733
× Sun, Jiayi× Jiang, Gandan |
|||||||||||
抄録 | ||||||||||||
内容記述タイプ | Abstract | |||||||||||
内容記述 | Nowadays, the incidence of Alzheimer’s disease (AD) and type 2 diabetes (T2D) is increasing at an alarming rate. More and more studies have been investigating the relationship between these two diseases and are trying to find an effective treatment. According to amyloid hypothesis, it is very necessary to find phenolic compounds with catechol moieties, which would inhibit the aggregation of amyloid β (Aβ) and human islet amyloid polypeptide (hIAPP), while also exhibiting antioxidant activity and protective effect. We isolated rosmarinic acid (RA) from the plant Isodon japonicus (Burm.f.) H. Hara. Thioflavin T assay and transmission electron microscopy observation were carried out to evaluate the inhibitory effect of RA, caffeic acid, and 3,4-dihydroxyphenyllactic acid, which are the substructures of RA, on both Aβ and hIAPP fibrillization. 2,2-Diphenyl-1-picrylhydrazyl assay was applied to test the antioxidant activity. RA showed inhibitory effect on both peptides and strong antioxidant activity. These results suggest that the existence of catechol units plays an important role on the inhibitory activity. Therefore, RA will be a promising strategy to prevent AD and T2D. | |||||||||||
書誌情報 |
Natural product communications 巻 14, 号 5, p. 1934578X1984303, 発行日 2019-05 |
|||||||||||
ISSN | ||||||||||||
収録物識別子タイプ | ISSN | |||||||||||
収録物識別子 | 1934-578X | |||||||||||
DOI | ||||||||||||
識別子タイプ | DOI | |||||||||||
関連識別子 | 10.1177/1934578X19843039 | |||||||||||
権利 | ||||||||||||
権利情報 | ©The Author(s) 2019 | |||||||||||
権利 | ||||||||||||
権利情報 | Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www. creativecommons. org/ licenses/ by- nc/ 4. 0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https:// us. sagepub. com/ en- us/ nam/ openaccess- at- sage). | |||||||||||
著者版フラグ | ||||||||||||
値 | publisher |