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Human papillomavirus genotype and prognosis of cervical cancer: Favorable survival of patients with HPV16-positive tumors
http://hdl.handle.net/2241/00154800
http://hdl.handle.net/2241/00154800704bd453-113c-4cbd-87cd-297172f8b599
名前 / ファイル | ライセンス | アクション |
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PR_6-41 (405.2 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2019-03-07 | |||||
タイトル | ||||||
タイトル | Human papillomavirus genotype and prognosis of cervical cancer: Favorable survival of patients with HPV16-positive tumors | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
秋山, 梓
× 秋山, 梓× 櫻井, 学× 水口, 剛雄× 沖, 明典× 佐藤, 豊実× 吉川, 裕之× Onuki, Mamiko× Matsumoto, Koji× Tenjimbayashi, Yuri× Tasaka, Nobutaka× Yoshikawa, Hiroyuki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The prognostic impact of human papillomavirus (HPV) type on invasive cervical cancer (ICC) was analyzed for 137 women treated for ICC at a single institution between 1999 and 2007. The study subjects were divided into three groups according to HPV genotype: HPV16-positive (n = 59), HPV18-positive (n = 33), and HPV16/18-negative ICC (non-HPV16/18, n = 45). The median follow-up time was 102.5 months (range, 5–179). The 10-year overall survival (10y-OS) rates in women with FIGO stage I/II disease were similar among HPV genotypes: 94.7% for HPV16 (n = 39), 95.2% for HPV18 (n = 26), and 96.4% for non-HPV16/18 (n = 29). However, the 10y-OS rates in women with FIGO stage III/IV tumors were 73.7% for HPV16 (n = 20), 45.7% for HPV18 (n = 7), and 35.7% for other types (n = 16), with significantly higher survival in HPV16-positive compared with HPV16-negative ICC (10y-OS; 73.7% vs. 39.5%, P = 0.04). This difference in FIGO stage III/IV tumors remained significant after adjusting for age and histology (hazard ratio 0.30, 95% confidence interval 0.09–0.86, P = 0.02). These results suggest that detection of HPV16 DNA may be associated with a favorable prognosis in patients with FIGO stage III/IV ICC. Given that most women with FIGO stage III/IV tumors received concurrent chemoradiotherapy, this finding may imply that HPV16-positive tumors are more chemoradiosensitive. | |||||
書誌情報 |
Papillomavirus Research 巻 6, p. 41-45, 発行日 2018-12 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 24058521 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 30347290 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.pvr.2018.10.005 | |||||
権利 | ||||||
権利情報 | © 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/). | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Elsevier |