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Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain
http://hdl.handle.net/2241/00153279
http://hdl.handle.net/2241/00153279c04d9915-303c-4537-a1bd-356fbf7bfade
名前 / ファイル | ライセンス | アクション |
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CR_24-1 (9.0 MB)
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Item type | Journal Article(1) | |||||||||||||||||||||||
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公開日 | 2018-09-25 | |||||||||||||||||||||||
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言語 | en | |||||||||||||||||||||||
タイトル | Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain | |||||||||||||||||||||||
言語 | ||||||||||||||||||||||||
言語 | eng | |||||||||||||||||||||||
資源タイプ | ||||||||||||||||||||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||
タイプ | journal article | |||||||||||||||||||||||
アクセス権 | ||||||||||||||||||||||||
アクセス権 | open access | |||||||||||||||||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||||||||
著者 |
Fujiyama, Tomoyuki
× Fujiyama, Tomoyuki× Miyashita, Satoshi× Tsuneoka, Yousuke× 金丸, 和正
WEKO
204174
× Kakizaki, Miyo× Kanno, Satomi× Ishikawa, Yukiko× Yamashita, Mariko× Owa, Tomoo× Nagaoka, Mai× Kawaguchi, Yoshiya× Yanagawa, Yuchio× Magnuson, Mark A.× 村谷, 匡史
WEKO
204931
× Shibuya, Akira× Nabeshima, Yo-ichi× 柳沢, 正史
WEKO
496
× Funato, Hiromasa× Hoshino, Mikio |
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抄録 | ||||||||||||||||||||||||
内容記述タイプ | Abstract | |||||||||||||||||||||||
内容記述 | The mammalian brain undergoes sexual differentiation by gonadal hormones during the perinatal critical period. However, the machinery at earlier stages has not been well studied. We found that Ptf1a is expressed in certain neuroepithelial cells and immature neurons around the third ventricle that give rise to various neurons in several hypothalamic nuclei. We show that conditional Ptf1a-deficient mice (Ptf1a cKO) exhibit abnormalities in sex-biased behaviors and reproductive organs in both sexes. Gonadal hormone administration to gonadectomized animals revealed that the abnormal behavior is caused by disorganized sexual development of the knockout brain. Accordingly, expression of sex-biased genes was severely altered in the cKO hypothalamus. In particular, Kiss1, important for sexual differentiation of the brain, was drastically reduced in the cKO hypothalamus, which may contribute to the observed phenotypes in the Ptf1a cKO. These findings suggest that forebrain Ptf1a is one of the earliest regulators for sexual differentiation of the brain. | |||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||
書誌情報 |
en : Cell Reports 巻 24, 号 1, p. 79-94, 発行日 2018-07 |
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ISSN | ||||||||||||||||||||||||
収録物識別子タイプ | PISSN | |||||||||||||||||||||||
収録物識別子 | 2211-1247 | |||||||||||||||||||||||
PubMed番号 | ||||||||||||||||||||||||
識別子タイプ | PMID | |||||||||||||||||||||||
関連識別子 | 29972793 | |||||||||||||||||||||||
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関連タイプ | isIdenticalTo | |||||||||||||||||||||||
識別子タイプ | DOI | |||||||||||||||||||||||
関連識別子 | https://doi.org/10.1016/j.celrep.2018.06.010 | |||||||||||||||||||||||
権利 | ||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||
権利情報 | (c)2018 The Authors | |||||||||||||||||||||||
権利 | ||||||||||||||||||||||||
言語 | en | |||||||||||||||||||||||
権利情報 | This is an open access article under the CC BY license (http://creativecommons.org/licenses/b y/4.0/). | |||||||||||||||||||||||
出版タイプ | ||||||||||||||||||||||||
出版タイプ | VoR | |||||||||||||||||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||||
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言語 | en | |||||||||||||||||||||||
出版者 | Cell Press |