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Novel functions of platelets in the liver
http://hdl.handle.net/2241/00151872
http://hdl.handle.net/2241/001518722016f8c0-a14f-442b-875d-84030de07810
名前 / ファイル | ライセンス | アクション |
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JGH_31-4 (246.8 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2018-06-01 | |||||
タイトル | ||||||
タイトル | Novel functions of platelets in the liver | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Kurokawa, Tomohiro
× Kurokawa, Tomohiro× Zheng, Yun-Wen× Ohkohchi, Nobuhiro |
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著者別名 |
鄭, 允文
× 鄭, 允文× 大河内, 信弘 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Platelets contain not only proteins needed for hemostasis but also many growth factors that are required for organ development, tissue regeneration, and repair. Thrombocytopenia, which is frequently observed in patients with chronic liver disease (CLD) and cirrhosis, is due to various causes, such as decreased thrombopoietin production and accelerated platelet destruction caused by hypersplenism; however, the relationship between thrombocytopenia and hepatic pathogenesis and the role of platelets in CLD are poorly understood. Thus, in this paper, the experimental evidence for platelets improving liver fibrosis and accelerating liver regeneration is summarized and addressed based on studies conducted in our laboratory and current progress reports from other investigators. Platelets improve liver fibrosis by inactivating hepatic stellate cells to decrease collagen production. The level of intracellular cAMP is increased by adenosine through its receptors on hepatic stellate cells, thereby resulting in inactivation of these cells. Adenosine is produced by degradation of adenine nucleotides, which are stored in abundance within the dense granules of platelets. The regenerative effect of platelets in the liver consists of three mechanisms: a direct effect on hepatocytes, a cooperative effect with liver sinusoidal endothelial cells, and a collaborative effect with Kupffer cells. Based on these experiments, a clinical trial suggested that the increase in platelets induced by platelet transfusion improved liver function in patients with CLD in a clinical setting.We highlight the current knowledge concerning the role of platelets in CLD and expect to open a novel avenue for application of these clinical therapies to treat liver disease. | |||||
書誌情報 |
Journal of gastroenterology and hepatology 巻 31, 号 4, p. 745-751, 発行日 2016-04 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0815-9319 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10727383 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 26632220 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1111/jgh.13244 | |||||
権利 | ||||||
権利情報 | © 2015 The Authors. Journal of Gastroenterology and Hepatology published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd | |||||
権利 | ||||||
権利情報 | This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Wiley |