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Hepatic histopathological changes and dysfunction in primates following exposure to organic arsenic diphenylarsinic acid
http://hdl.handle.net/2241/00151668
http://hdl.handle.net/2241/0015166839b69973-903f-44fe-8280-efbcbeac822d
名前 / ファイル | ライセンス | アクション |
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JTC_43-291 (3.6 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2018-05-15 | |||||
タイトル | ||||||
タイトル | Hepatic histopathological changes and dysfunction in primates following exposure to organic arsenic diphenylarsinic acid | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Masuda, Tomoyuki
× Masuda, Tomoyuki× Ishii, Kazuhiro× Morishita, Yukio× Iwasaki, Nobuaki× Shibata, Yasuyuki× Tamaoka, Akira |
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著者別名 |
増田, 知之
× 増田, 知之× 石井, 一弘× 玉岡, 晃 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Organic arsenic diphenylarsinic acid (DPAA[V]) accumulates at high concentrations in the liver of primates after its subchronic administration. However, no studies on the hepatic effects of organic arsenic compounds, including DPAA(V), on primates have been reported to date. To clarify the toxicokinetics of DPAA(V) in the liver of primates, hepatic tissue specimens were collected from cynomolgus monkeys (n = 32) at 5, 29, 170, and 339 days after repeated administration of DPAA(V) for 28 days. Four histopathological changes in the specimens were observed and pathologically evaluated. Atypical ductular proliferation was found in the DPAA(V)-exposed liver throughout the period. Inflammatory cell infiltration in Glisson’s capsules and lipid droplets were seen at earlier periods after administration. Conversely, inflammatory cell infiltration in liver lobules was seen later after administration. In this experiment, we did not confirm the hepatic dysfunction of DPAA(V)-exposed monkeys by blood chemistry tests. To compensate for this, we further investigated the blood from a patient who exhibited several neurological symptoms after DPAA(V) exposure. Her blood chemistry test values for aspartate transaminase, alanine transaminase, and lactate dehydrogenase were elevated, suggesting that her liver may have been damaged by DPAA(V) exposure. Together, these findings suggest that the accumulation of DPAA(V) may induce differential histopathological changes in primate hepatocytes, resulting in decreased liver function. This is the first report to investigate the liver of primates pathologically after exposure to organic arsenic DPAA(V). Our findings will help expand our knowledge regarding the effect of DPAA(V) on the liver of primates. | |||||
書誌情報 |
The journal of toxicological sciences 巻 43, 号 5, p. 291-298, 発行日 2018-02 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0388-1350 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00002808 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.2131/jts.43.291 | |||||
権利 | ||||||
権利情報 | © 2018 The Japanese Society of Toxicology | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | 日本毒性学会 |