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Co-chaperone BAG2 Determines the Pro-oncogenic Role of Cathepsin B in Triple-Negative Breast Cancer Cells
http://hdl.handle.net/2241/00149875
http://hdl.handle.net/2241/00149875791383b4-e653-4a81-9e58-03ecce110a90
名前 / ファイル | ライセンス | アクション |
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CR_21-10 (5.7 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2018-01-04 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Co-chaperone BAG2 Determines the Pro-oncogenic Role of Cathepsin B in Triple-Negative Breast Cancer Cells | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
Yang, Kyung-Min
× Yang, Kyung-Min× Bae, Eunjin× Ahn, Sung Gwe× Pang, Kyoungwha× Park, Yuna× Park, Jinah× Lee, Jihee× Ooshima, Akira× Park, Bora× Kim, Junil× Jung, Yunshin× 高橋, 智× Jeong, Joon× Park, Seok Hee× Kim, Seong-Jin |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Triple-negative breast cancer (TNBC) is considered incurable with currently available treatments, highlighting the need for therapeutic targets and predictive biomarkers. Here, we report a unique role for Bcl-2-associated athanogene 2 (BAG2), which is significantly overexpressed in TNBC, in regulating the dual functions of cathepsin B as either a pro- or anti-oncogenic enzyme. Silencing BAG2 suppresses tumorigenesis and lung metastasis and induces apoptosis by increasing the intracellular mature form of cathepsin B, whereas BAG2 expression induces metastasis by blocking the auto-cleavage processing of pro-cathepsin B via interaction with the propeptide region. BAG2 regulates pro-cathepsin B/annexin II complex formation and facilitates the trafficking of pro-cathespin-B-containing TGN38-positive vesicles toward the cell periphery, leading to the secretion of pro-cathepsin B, which induces metastasis. Collectively, our results uncover BAG2 as a regulator of the oncogenic function of pro-cathepsin B and a potential diagnostic and therapeutic target that may reduce the burden of metastatic breast cancer. | |||||
言語 | en | |||||
書誌情報 |
en : Cell Reports 巻 21, 号 10, p. 2952-2964, 発行日 2017-12 |
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ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 2211-1247 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 29212038 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.celrep.2017.11.026 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | (c) 2017 The Author(s). | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ ). | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Cell Press |