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Upregulation of Mitf by Phenolic Compounds-Rich Cymbopogon schoenanthus Treatment Promotes Melanogenesis in B16 Melanoma Cells and Human Epidermal Melanocytes
http://hdl.handle.net/2241/00149269
http://hdl.handle.net/2241/001492693196cc70-32a7-479e-a003-07253bc6e656
名前 / ファイル | ライセンス | アクション |
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BMRI_2017-8303671 (2.0 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2017-12-08 | |||||
タイトル | ||||||
タイトル | Upregulation of Mitf by Phenolic Compounds-Rich Cymbopogon schoenanthus Treatment Promotes Melanogenesis in B16 Melanoma Cells and Human Epidermal Melanocytes | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Villareal, Myra O.
× Villareal, Myra O.× Kume, Sayuri× Neffati, Mohamed× Isoda, Hiroko |
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著者別名 |
ブリリアル, マイラ
× ブリリアル, マイラ× 礒田, 博子 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Melanin provides inherent protection against skin cancer by absorbing broad-spectrum radiant energy of UV radiation. Cutaneous malignant melanoma incidence has recently been observed to increase and the frequency is closely associated with the skin color, highlighting the importance of skin pigmentation. Here, we showed how melanin biosynthesis is enhanced by treatment with phenolic compounds-rich Cymbopogon schoenanthus (CYM) in B16 murine melanoma cells and human epidermal melanocytes (HEM). CYM increased the melanin content of the cells by upregulating the expression of tyrosinase (TYR), tyrosinase-related protein 1 (TRP1), and dopachrome tautomerase (DCT) at the protein and mRNA levels, comparable to the effect of α-melanocyte-stimulating hormone (MSH), in both B16 cells and HEM. Moreover, global gene expression analysis showed that at least 44 pigmentation-associated genes were modulated, including the microphthalmia-associated transcription factor (Mitf) and its transcriptional regulators (Sox10, Pax3, and Lef1). Upregulation of copper transport-associated gene Atp7b indicates that CYM also promotes tyrosinase activity. CYM upregulated Mitf and possibly activates tyrosinase enzyme, providing evidence for its possible use to promote melanogenesis and as a therapeutic agent against hypopigmentation disorders. | |||||
書誌情報 |
BioMed Research International 巻 2017, p. 8303671, 発行日 2017-11 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2314-6133 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1155/2017/8303671 | |||||
権利 | ||||||
権利情報 | © 2017 Myra O. Villareal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Hindawi Publishing Corporation |