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Inhibitory Effects of Polyacetylene Compounds from Panax ginseng on Neurotrophin Receptor-Mediated Hair Growth
http://hdl.handle.net/2241/00148588
http://hdl.handle.net/2241/00148588558c3d76-15d2-48bb-a0cb-2a1384c030b1
名前 / ファイル | ライセンス | アクション |
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BPB_40-10 (571.3 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2017-10-27 | |||||
タイトル | ||||||
タイトル | Inhibitory Effects of Polyacetylene Compounds from Panax ginseng on Neurotrophin Receptor-Mediated Hair Growth | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Suzuki, Aoi
× Suzuki, Aoi× Matsuura, Daisuke× Kanatani, Hirotoshi× Yano, Shingo× Tsunakawa, Mitsuo× Matsuyama, Shigeru× Shigemori, Hideyuki |
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著者別名 |
松山, 茂
× 松山, 茂× 繁森, 英幸 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Neurotrophins play an important role in the control of the hair growth cycle. Therefore, neurotrophin receptor antagonists have therapeutic potential for the treatment of hair growth disorders. In this study, we investigated the inhibitory effect of Panax ginseng, a medicinal plant commonly used to treat alopecia, on the binding of neurotrophins to their receptors. In addition, we isolated and characterized the bioactive compounds of P. ginseng extracts. P. ginseng hexane extracts strongly inhibited brain-derived neurotrophic factor (BDNF)-TrkB and β-nerve growth factor (β-NGF)-p75 neurotrophin receptor (p75NTR) binding. Furthermore, we identified the following 6 polyacetylene compounds as the bioactive components in P. ginseng hexane extract: panaxynol (1), panaxydol (2), panaxydol chlorohydrin (3), 1,8-heptadecadiene-4,6-diyne-3,10-diol (4), panaxytriol (5), and dihydropanaxacol (6). In particular, compounds 4, 5, and 6 significantly inhibited BDNF-TrkB binding in a dose-dependent manner. To identify the structural component mediating the inhibitory effect, we investigated the effects of the hydroxyl moiety in these compounds. We found that the inhibitory effect of panaxytriol (5) was strong, whereas the inhibitory effect of Ac-panaxytriol (7) was relatively weak. Our findings suggest that P. ginseng-derived polyacetylenes with a hydroxyl moiety might provide therapeutic benefits to patients with hair growth disorders such as alopecia by inhibiting the binding of neurotrophins to their receptors. Although saponins have been proposed to be the primary mediators of the effects of P. ginseng on hair growth, this study revealed that polyacetylene compounds exert similar effects. | |||||
書誌情報 |
Biological & pharmaceutical bulletin 巻 40, 号 10, p. 1784-1788, 発行日 2017-10 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0918-6158 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10885497 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 28966252 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1248/bpb.b17-00205 | |||||
権利 | ||||||
権利情報 | © 2017 The Pharmaceutical Society of Japan | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Pharmaceutical Society of Japan |