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Effect of Keishibukuryogan, a Japanese Traditional Kampo Prescription, on Improvement of Microcirculation and Oketsu and Induction of Endothelial Nitric Oxide: A Live Imaging Study
http://hdl.handle.net/2241/00147078
http://hdl.handle.net/2241/001470782ede8372-8685-461e-98a0-619a9b982430
名前 / ファイル | ライセンス | アクション |
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E-BCAM_2017 (3.1 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2017-08-08 | |||||
タイトル | ||||||
タイトル | Effect of Keishibukuryogan, a Japanese Traditional Kampo Prescription, on Improvement of Microcirculation and Oketsu and Induction of Endothelial Nitric Oxide: A Live Imaging Study | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Tomita, Tsutomu
× Tomita, Tsutomu× Hirayama, Aki× Matsui, Hirofumi× Aoyagi, Kazumasa |
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著者別名 |
松井, 裕史
× 松井, 裕史 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Oketsu is a characteristic condition that plays an important role in Kampo, Japanese traditional medicine, and includes multiple aspects of hemodynamic disorders. This study aims to clarify the microcirculation of Oketsu and the pharmacological effect of Keishibukuryogan, an anti-Oketsu Kampo prescription, using live imaging techniques. Oral administration of Keishibukuryogan induced significant vasodilation of murine subcutaneous arterioles compared to the preadministration level. This vasodilatation peaked 60 min after administration and persisted for 90 min. The blood velocity in the subcutaneous capillary was also increased by Keishibukuryogan in generally the same manner. In rat mesenteric arterioles, Keishibukuryogan administration improved microhemodynamic parameters, including the resolution of erythrocyte congestion and the cell-free layer, which are representative of Oketsu pathology. Live imaging revealed an increase of diaminofluorescein-2 diacetate fluorescence, a nitric oxide (NO) specific reagent, in the arterial endothelium following Keishibukuryogan administration. This fluorescence was most remarkable at vascular bifurcations but was present throughout the mesenteric arterioles. This study demonstrates the successful imaging of Oketsu pathology with respect to microcirculation and the anti-Oketsu effects of Keishibukuryogan, namely, vasodilation of arterioles, increased blood velocity, and resolution of erythrocyte congestion. The anti-Oketsu effect of Keishibukuryogan is related to endothelial NO production. | |||||
書誌情報 |
Evidence-based complementary and alternative medicine 巻 2017, p. 3620130, 発行日 2017-07 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1741-427X | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11968793 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1155/2017/3620130 | |||||
権利 | ||||||
権利情報 | © 2017 Tsutomu Tomita et al. | |||||
権利 | ||||||
権利情報 | This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | Hindawi Publishing Corporation |