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Numerical analysis of bursting activity in an isolated pancreatic β-cell model
http://hdl.handle.net/2241/00146055
http://hdl.handle.net/2241/0014605584c68514-b4e8-47d2-bd10-1e44ca796620
名前 / ファイル | ライセンス | アクション |
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IEICENTIA_7-2 (1.6 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2017-05-11 | |||||
タイトル | ||||||
タイトル | Numerical analysis of bursting activity in an isolated pancreatic β-cell model | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Ando, Hiroyasu
× Ando, Hiroyasu× Fujiwara, Kantaro |
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著者別名 |
安東, 弘泰
× 安東, 弘泰 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Pancreatic β-cells exhibit bursting electrical activity, which is correlated with insulin secretion. It has been reported that several ionic channels may contribute to the characteristic electrical activities of these cells but their mechanisms are still unclear. In this study, we examined how the characteristic electrical activity of isolated β-cells occurs. Using a simple mathematical model of pancreatic β-cells, we found that conductances of the voltage-sensitive mixed ion channel and voltage-sensitive potassium channel contribute to such electrical activity. In addition, we found that noise can play a key role in this activity. These results imply that the bursting electrical activity of pancreatic β-cells can be controlled by ionic conductances or noise. Such control enables medical application of β-cells in type II diabetes, wherein insulin secretion is difficult to control. Our findings may contribute to a novel treatment for type II diabetes. | |||||
書誌情報 |
Nonlinear Theory and Its Applications, IEICE 巻 7, 号 2, p. 217-225, 発行日 2016-04 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2185-4106 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1587/nolta.7.217 | |||||
権利 | ||||||
権利情報 | © 2016 The Institute of Electronics, Information and Communication Engineers | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | The Institute of Electronics, Information and Communication Engineers |