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Krebs Cycle Intermediates Protective against Oxidative Stress by Modulating the Level of Reactive Oxygen Species in Neuronal HT22 Cells
http://hdl.handle.net/2241/00146039
http://hdl.handle.net/2241/001460394ecf6c6d-80af-4c41-b750-9508e3d9e643
名前 / ファイル | ライセンス | アクション |
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ANT_6-1 (644.0 kB)
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Item type | Journal Article(1) | |||||
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公開日 | 2017-05-09 | |||||
タイトル | ||||||
タイトル | Krebs Cycle Intermediates Protective against Oxidative Stress by Modulating the Level of Reactive Oxygen Species in Neuronal HT22 Cells | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
著者 |
Sawa, Kenta
× Sawa, Kenta× Uematsu, Takumi× Korenaga, Yusuke× Hirasawa, Ryuya× Kikuchi, Masatoshi× Murata, Kyohei× Zhang, Jian× Gai, Xiaoqing× Sakamoto, Kazuichi× Koyama, Tomoyuki× Satoh, Takumi |
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著者別名 |
坂本, 和一
× 坂本, 和一 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Krebs cycle intermediates (KCIs) are reported to function as energy substrates in mitochondria and to exert antioxidants effects on the brain. The present study was designed to identify which KCIs are effective neuroprotective compounds against oxidative stress in neuronal cells. Here we found that pyruvate, oxaloacetate, and α-ketoglutarate, but not lactate, citrate, iso-citrate, succinate, fumarate, or malate, protected HT22 cells against hydrogen peroxide-mediated toxicity. These three intermediates reduced the production of hydrogen peroxide-activated reactive oxygen species, measured in terms of 2′,7′-dichlorofluorescein diacetate fluorescence. In contrast, none of the KCIs—used at 1 mM—protected against cell death induced by high concentrations of glutamate—another type of oxidative stress-induced neuronal cell death. Because these protective KCIs did not have any toxic effects (at least up to 10 mM), they have potential use for therapeutic intervention against chronic neurodegenerative diseases. | |||||
書誌情報 |
Antioxidants 巻 6, 号 1, p. 21, 発行日 2017-03 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 2076-3921 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 28300753 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3390/antiox6010021 | |||||
権利 | ||||||
権利情報 | © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | |||||
著者版フラグ | ||||||
値 | publisher | |||||
出版者 | ||||||
出版者 | MDPI AG |