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KLF15 Enables Rapid Switching between Lipogenesis and Gluconeogenesis during Fasting
http://hdl.handle.net/2241/00144139
http://hdl.handle.net/2241/0014413910c296cd-3ad6-4744-a924-ab7d15b560e9
名前 / ファイル | ライセンス | アクション |
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CR_16-9 (4.1 MB)
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Item type | Journal Article(1) | |||||||||||
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公開日 | 2016-10-19 | |||||||||||
タイトル | ||||||||||||
言語 | en | |||||||||||
タイトル | KLF15 Enables Rapid Switching between Lipogenesis and Gluconeogenesis during Fasting | |||||||||||
言語 | ||||||||||||
言語 | eng | |||||||||||
資源タイプ | ||||||||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
タイプ | journal article | |||||||||||
アクセス権 | ||||||||||||
アクセス権 | open access | |||||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
著者 |
武内, 謙憲
× 武内, 謙憲
WEKO
204488
× 矢作, 直也× 會田, 雄一× Murayama, Yuki× Sawada, Yoshikazu× Piao, Xiaoying× Toya, Naoki× Oya, Yukari× Shikama, Akito× Takarada, Ayako× Masuda, Yukari× Nishi, Makiko× Kubota, Midori× Izumida, Yoshihiko× Yamamoto, Takashi× Sekiya, Motohiro× Matsuzaka, Takashi× Nakagawa, Yoshimi× Urayama, Osamu× Kawakami, Yasushi× Iizuka, Yoko× Gotoda, Takanari× Itaka, Keiji× Kataoka, Kazunori× Nagai, Ryozo× Kadowaki, Takashi× Yamada, Nobuhiro× Lu, Yuan× Jain, Mukesh?K.× Shimano, Hitoshi |
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抄録 | ||||||||||||
内容記述タイプ | Abstract | |||||||||||
内容記述 | Hepatic lipogenesis is nutritionally regulated (i.e., downregulated during fasting and upregulated during the postprandial state) as an adaptation to the nutritional environment. While alterations in the expression level of the transcription factor SREBP-1c are known to be critical for nutritionally regulated lipogenesis, upstream mechanisms governing Srebf1 expression remain unclear. Here, we show that the fasting-induced transcription factor KLF15, a key regulator of gluconeogenesis, forms a complex with LXR/RXR, specifically on the Srebf1 promoter. This complex recruits the corepressor RIP140 instead of the coactivator SRC1, resulting in reduced Srebf1 and thus downstream lipogenic enzyme expression during the early and euglycemic period of fasting prior to hypoglycemia and PKA activation. Through this mechanism, KLF15 overexpression specifically ameliorates hypertriglyceridemia without affecting LXR-mediated cholesterol metabolism. These findings reveal a key molecular link between glucose and lipid metabolism and have therapeutic implications for the treatment of hyperlipidemia. | |||||||||||
言語 | en | |||||||||||
書誌情報 |
en : Cell Reports 巻 16, 号 9, p. 2373-2386, 発行日 2016-08 |
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ISSN | ||||||||||||
収録物識別子タイプ | PISSN | |||||||||||
収録物識別子 | 2211-1247 | |||||||||||
PubMed番号 | ||||||||||||
識別子タイプ | PMID | |||||||||||
関連識別子 | 27545894 | |||||||||||
DOI | ||||||||||||
関連タイプ | isIdenticalTo | |||||||||||
識別子タイプ | DOI | |||||||||||
関連識別子 | https://doi.org/10.1016/j.celrep.2016.07.069 | |||||||||||
権利 | ||||||||||||
言語 | en | |||||||||||
権利情報 | (c) 2016 The Authors. | |||||||||||
権利 | ||||||||||||
言語 | en | |||||||||||
権利情報 | This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | |||||||||||
出版タイプ | ||||||||||||
出版タイプ | VoR | |||||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
出版者 | ||||||||||||
言語 | en | |||||||||||
出版者 | Cell Press |