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Nociceptor-Enriched Genes Required for Normal Thermal Nociception
http://hdl.handle.net/2241/00143832
http://hdl.handle.net/2241/001438327a59dc4b-9e6f-4984-8e4a-cfe2f930d992
名前 / ファイル | ライセンス | アクション |
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CR_16-2 (2.6 MB)
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Item type | Journal Article(1) | |||||
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公開日 | 2016-09-09 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Nociceptor-Enriched Genes Required for Normal Thermal Nociception | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源 | http://purl.org/coar/resource_type/c_6501 | |||||
タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
本庄, 賢
× 本庄, 賢× Mauthner, Stephanie?E.× Wang, Yu× Skene, J.H.?Pate× Tracey, W.?Daniel |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Here, we describe a targeted reverse genetic screen for thermal nociception genes in Drosophila larvae. Using laser capture microdissection and microarray analyses of nociceptive and non-nociceptive neurons, we identified 275 nociceptor-enriched genes. We then tested the function of the enriched genes with nociceptor-specific RNAi and thermal nociception assays. Tissue-specific RNAi targeted against 14 genes caused insensitive thermal nociception while targeting of 22 genes caused hypersensitive thermal nociception. Previously uncategorized genes were named for heat resistance (i.e., boilerman, fire dancer, oven mitt, trivet, thawb, and bunker gear) or heat sensitivity (firelighter, black match, eucalyptus, primacord, jet fuel, detonator, gasoline, smoke alarm, and jetboil). Insensitive nociception phenotypes were often associated with severely reduced branching of nociceptor neurites and hyperbranched dendrites were seen in two of the hypersensitive cases. Many genes that we identified are conserved in mammals. | |||||
言語 | en | |||||
書誌情報 |
en : Cell Reports 巻 16, 号 2, p. 295-303, 発行日 2016-07 |
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ISSN | ||||||
収録物識別子タイプ | PISSN | |||||
収録物識別子 | 2211-1247 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 27346357 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | https://doi.org/10.1016/j.celrep.2016.06.003 | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | (c) 2016 The Author(s). | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | |||||
出版タイプ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
言語 | en | |||||
出版者 | Cell Press |